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| | DIPHENYLCYCLOPROPENONE Basic information |
| | DIPHENYLCYCLOPROPENONE Chemical Properties |
| Melting point | 118-122 °C (lit.) | | Boiling point | 305.09°C (rough estimate) | | density | 1.232 | | refractive index | 1.6324 (estimate) | | storage temp. | Store below +30°C. | | solubility | DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM)
Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM) | | form | Crystalline Powder | | color | Slightly pinkish-orange to beige | | Merck | 14,3308 | | BRN | 608049 | | InChIKey | HCIBTBXNLVOFER-UHFFFAOYSA-N | | LogP | 1.769 (est) | | CAS DataBase Reference | 886-38-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 38-43 | | Safety Statements | 36/37 | | WGK Germany | 3 | | HS Code | 29142990 |
| | DIPHENYLCYCLOPROPENONE Usage And Synthesis |
| Description | Diphencyprone is a potent contact allergen responsible
for occupational contact dermatitis in chemists and
dermatological staff.
| | Description | Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta. | | Chemical Properties | slightly pinkish-orange to beige crystalline | | Uses | Diphenylcyclopropenone was used in topical immunotherapy. | | Definition | ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions. | | General Description | Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated. | | Contact allergens | Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff | | Purification Methods | Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.] |
| | DIPHENYLCYCLOPROPENONE Preparation Products And Raw materials |
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