ChemicalBook Product Catalog Organic Chemistry 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline

4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Basic information
Product Name:4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline
Synonyms:4-chloro-6,7-bis(2-methoxyethoxy)quinazoline;4-Chloro-6,7-(2-methoxyethoxy)quinazoline;4-Chloro-6,7-bis(2-methoxyethoxy)quinazolin;6,7-Bis(2-methoxyethoxy)-4-chloroquinazoline;Erlotinib Intermediate 1;4-chloro-6,7-di(2-methoxyethoxy)quinazoline;CP-335963;PF-508367
CAS:183322-18-1
MF:C14H17ClN2O4
MW:312.75
EINECS:605-994-5
Product Categories:API intermediates;Intermediate of erlotinib hydrochloride;intermidiate of Erlotinib hydrochloride
Mol File:183322-18-1.mol
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Structure
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Properties
Melting point 105-107 °C
Boiling point 446.7±45.0 °C(Predicted)
density 1.257
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO: ≥20mg/mL
form powder
pka0.54±0.30(Predicted)
color white to off-white
InChIInChI=1S/C14H17ClN2O4/c1-18-3-5-20-12-7-10-11(16-9-17-14(10)15)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3
InChIKeyZPJLDMNVDPGZIU-UHFFFAOYSA-N
SMILESN1=C2C(C=C(OCCOC)C(OCCOC)=C2)=C(Cl)N=C1
CAS DataBase Reference183322-18-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 3
HS Code 2933599590
MSDS Information
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Usage And Synthesis
Uses4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Preparation Products And Raw materials
Preparation ProductsErlotinib
Erlotinib iMpurity 2 Erlotinib hydrochloride 3-Aminophenylacetylene 6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone 3-Ethynylbenzenamine hydrochloride 4-Chloro-7-methoxyquinazoline Quinoxaline 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-CHLORO-6-HYDROXYQUINAZOLINE 6-METHOXY-QUINAZOLIN-4-YLAMINE Cefazolin 4-Chloro-6,7-dimethoxyquinazoline Difluorochloromethane 4-CHLORO-7-HYDROXYQUINAZOLINE Cefazolin sodium salt Erlotinib 4-CHLORO-6-ETHOXY-QUINAZOLINE 6-Hydroxyl-7-Ethoxyquinazoline-4-One
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