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| | Epitiostanol Basic information |
| Product Name: | Epitiostanol | | Synonyms: | 2alpha,3alpha-Epithio-5alpha-androstan-17beta-ol;Epithioandrostanol;Epitiostanol;10275S;2,3-Epithio-1H-cyclopenta[a]phenanthrene, androstan-17-ol deriv.;2α,3α-Epithio-5α-androstan-17β-ol;5α-Androstan-17β-ol, 2α,3α-epithio- (7CI, 8CI);Androstan-17-ol, 2,3-epithio-, (2α,3α,5α,17β)- | | CAS: | 2363-58-8 | | MF: | C19H30OS | | MW: | 306.51 | | EINECS: | | | Product Categories: | Inhiitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Sulfur & Selenium Compounds | | Mol File: | 2363-58-8.mol |  |
| | Epitiostanol Chemical Properties |
| Melting point | 127-128° | | alpha | D27.5 +24.4° (c = 1.054 in chloroform) | | Boiling point | 417.1°C (rough estimate) | | density | 1.0122 (rough estimate) | | refractive index | 1.5700 (estimate) | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 15.10±0.60(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | 1.2mg/L(37 ºC) |
| Toxicity | LD50 in mice, rats (mg/kg): 1, 5 i.p. (Minesita, p 805) |
| | Epitiostanol Usage And Synthesis |
| Originator | Thiodrol,Shionogi,Japan,1977 | | Uses | An anabolic steroid that exhibits androgenic, myogenic, anabolic, anticatabolic, progestational, deciduomatogenic, and antiestrogenic activities. An anti-estrogen with anti-mammry cancer agent. | | Definition | ChEBI: Epitiostanol is an organic molecular entity. | | Manufacturing Process | A solution of 2β-thiocyanato-3α-methanesulfonyloxy-5α-androstan-17β-ol 17-
acetate (0.82 part by weight) and potassium hydroxide (0.9 part by weight) in
diglyme (20 parts by volume) is refluxed on a water bath for 24 hours while
stirring. To the reaction mixture, there is added water, and the separated
substance is collected by filtration and crystallized from hexane to give 2β,3β-
epithio-5α-androstan-17β-ol (0.60 part by weight) as crystals melting at
132.5°C to 134°C. | | Therapeutic Function | Antineoplastic |
| | Epitiostanol Preparation Products And Raw materials |
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