1,3-Difluorobenzene

1,3-Difluorobenzene Basic information
Synthesis Chemical Properties Uses
Product Name:1,3-Difluorobenzene
Synonyms:1,3-difluroethylene;Benzene, m-difluoro-;benzene,1,3-difluoro-;Benzene,m-difluoro-;Between two fluorine benzene;1,3-DifL;Difluoro-1,3-benzene;m-difluoro-benzen
CAS:372-18-9
MF:C6H4F2
MW:114.09
EINECS:206-746-5
Product Categories:Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Aromatic Hydrocarbons (substituted) & Derivatives;Fluorobenzene;Fluorine Compounds;Aryl;C6;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;alkyl Fluorine;Halogenated Hydrocarbons;bc0001;K00001
Mol File:372-18-9.mol
1,3-Difluorobenzene Structure
1,3-Difluorobenzene Chemical Properties
Melting point -59 °C
Boiling point 83 °C
density 1.163 g/mL at 25 °C(lit.)
vapor pressure 11.034-19.924kPa at 20-38.2℃
refractive index n20/D 1.438(lit.)
Fp 36 °F
storage temp. Flammables area
solubility 1.1g/l
form Liquid
Specific Gravity1.163
color Clear colorless to yellow
Water Solubility insoluble
BRN 1904537
LogP2.21-2.52 at 25℃ and pH6.5
CAS DataBase Reference372-18-9(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, 1,3-difluoro-(372-18-9)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20-2017/11/20
Safety Statements 7-16-29-33-7/9
RIDADR UN 1993 3/PG 2
WGK Germany 1
RTECS CZ5652000
Hazard Note Highly Flammable
HazardClass 3
PackingGroup II
HS Code 29036990
MSDS Information
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1,3-Difluorobenzene English
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1,3-Difluorobenzene Usage And Synthesis
SynthesisHigher yields were observed when CsF and HF were reacted with 1,3-dichlorobenzene, which gave I ,3-difluorobenzene.
synthesis of 1,3-Difluorobenzene
Chemical Properties

1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yellowish liquid. Its melting point is -59 °C, boiling point is 83 °C and flash point is 2 oC. It is insoluble in water and stable under normal temperatures and pressures. It is toxic and flammable. It will produce toxic fluoride gas by heat.

Uses

1,3-Difluorobenzene has been extensively used in the synthesis of pharmaceutical and pesticide intermediate. For example, it can be used for the synthesis of fluorinated medicine such as Fluconazole, etc. and pesticide (Flucycloxuron, Diflubenzuro, etc.). It can also be used to synthesize liquid crystal materials.

Chemical PropertiesCLEAR COLORLESS TO YELLOWISH LIQUID
UsesIt is used in the laser induced fluorencence matrix study of 1,3-difluorobenzene radical cation. It is also used synthesis of 1,2,3-triazole containing fluconazole analogues.
DefinitionChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 3.
Pentafluorobenzene Decafluorobiphenyl 2,6-Difluorophenol PENTAFLUOROPHENYL SULFIDE Bromopentafluorobenzene 1,2,3,4-Tetrafluorobenzene DIPHENYL(PENTAFLUOROPHENYL)PHOSPHINE DECAFLUOROBENZOPHENONE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE 2,3,4,5,6-PENTAFLUOROANISOLE 2,3,4,5,6-PENTAFLUOROTOLUENE 2,6-Difluorobenzonitrile 2-Difluorobenzene,1,2-Difluorobenzene 98%,1,2-Difluorobenzene,98+%,o-Difluorobenzene,99% BIS(PENTAFLUOROPHENYL)PHENYLPHOSPHINE α,α-Difluorophenylacetic acid Florfenicol 2,3,4,5,6-PENTAFLUOROBENZOPHENONE DECAFLUOROBENZHYDROL

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