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N-Acetyl-L-leucine

N-Acetyl-L-leucine Basic information
Product Name:N-Acetyl-L-leucine
Synonyms:AKOS BBS-00004735;ACETYL-DL-LEUCINE, N-;ACETYL-DL-LEUCINE;ACETYL-L-LEUCINE;AC-DL-LEU-OH;AC-LEUCINE;AC-LEU-OH;IFLAB-BB F0777-0821
CAS:1188-21-2
MF:C8H15NO3
MW:173.21
EINECS:214-706-3
Product Categories:N-Acetyl-Amino acid series;Amino Acid Derivatives;Leucine [Leu, L];Amino Acids and Derivatives;Leucine;Peptide Synthesis;Amino Acids Derivatives;Amino Acid Derivatives;Amino Acids;Ac-Amino Acids;Amino Acids (N-Protected);Biochemistry;amino acid;amino;bc0001;1188-21-2
Mol File:1188-21-2.mol
N-Acetyl-L-leucine Structure
N-Acetyl-L-leucine Chemical Properties
Melting point 187-190 °C(lit.)
alpha -24.5 º (c=4, MeOH)
Boiling point 303.86°C (rough estimate)
density 1.1599 (rough estimate)
refractive index -22 ° (C=5, EtOH)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
pka3.67±0.10(Predicted)
form Crystalline Powder
color White
optical activity[α]25/D 23±3°, c = 2 in ethanol
Water Solubility 0.81 g/100 mL (20 ºC)
BRN 1724849
CAS DataBase Reference1188-21-2(CAS DataBase Reference)
NIST Chemistry ReferenceL-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry SystemL-Leucine, N-acetyl- (1188-21-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
TSCA Yes
HazardClass IRRITANT
HS Code 29241900
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
N-Acetyl-L-leucine Usage And Synthesis
Chemical PropertiesWhite crystalline powder
UsesN-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.
DefinitionChEBI: The N-acetyl derivative of L-leucine.
N-Acetyl-L-leucine Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Methanol-->Acetic anhydride-->L-Leucine
H-HIS-LEU-OH N-L-gamma-Glutamyl-L-leucine Z-ALA-LEU-OH H-ASP-LEU-OH H-GLY-LEU-GLY-LEU-OH H-PRO-LEU-OH Z-LEU-LEU-OH HIPPURYL-HIS-LEU H-TYR-LEU-OH CHLOROACETYL-L-LEUCINE THR-VAL-LEU H-GLY-ALA-LEU-OH H-MET-LEU-OH ACETYL-L-LEUCINE METHYL ESTER,N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER,N-Acetyl-L-leucine methyl ester H-TRP-LEU-OH H-VAL-LEU-OH H-LEU-TRP-LEU-OH N-CBZ-LEU-LEU METHYL ESTER
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