5-Nitro-1,10-phenanthroline

5-Nitro-1,10-phenanthroline Basic information
Product Name:5-Nitro-1,10-phenanthroline
Synonyms:5-NITRO-1,10-PHENANTHROLINE;5-nitro-10-phenanthroline;NITROFERROIN;TIMTEC-BB SBB008850;5-NITRO-1 10-PHENANTHROLINE HYDRATE &;5-Nitro-1,10-phenanthroline,98%;1,10-Phenanthroline, 5-nitro-;5-Nitro-1,10-phenathroline
CAS:4199-88-6
MF:C12H7N3O2
MW:225.2
EINECS:224-097-6
Product Categories:
Mol File:4199-88-6.mol
5-Nitro-1,10-phenanthroline Structure
5-Nitro-1,10-phenanthroline Chemical Properties
Melting point 202-204 °C(lit.)
Boiling point 366.71°C (rough estimate)
density 1.2844 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Alcohol,Benzene
form crystalline
pkapK1:3.232(+1) (25°C)
color yellow to orange
Water Solubility insoluble
BRN 196245
CAS DataBase Reference4199-88-6(CAS DataBase Reference)
EPA Substance Registry System1,10-Phenanthroline, 5-nitro- (4199-88-6)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-40
Safety Statements 26-36-24/25-22
WGK Germany 3
TSCA Yes
HS Code 29339900
MSDS Information
ProviderLanguage
Nitro-ferroin English
ACROS English
ALFA English
5-Nitro-1,10-phenanthroline Usage And Synthesis
Chemical PropertiesLight yellow to yellow-brown crystalline powder
Uses5-Nitro-1,10-phenanthroline complexes of iron find wide applications in redox titrations. It is used as a precursor for the synthesis of 5-amino-1,10-phenanthroline, 5-isothiocyanato-1,10-phenanthroline.
Biochem/physiol ActionsPlatinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of cytotoxicity.
Purification MethodsCrystallise the phenanthroline from *benzene/pet ether, until anhydrous. It also crystallises from H2O with m 202o, and EtOAc with m 203o. Its pK2 5 varies from 3.20 to 2.69 with varying MeOH/H2O ratios from 0 to 0.95 moles/L, and from 3.20 to 1.95 in varying EtOH/H2O ratios from 0 to 0.94 moles/L [Ram et al. J Prakt Chem 319 719 1977]. It forms complexes with Cu2+, Zn2+, In2+, Fe2+ , Co2+, Ni2+ . [Beilstein 23 III/IV 1682, 23/8 V 425.]
5-Nitro-1,10-phenanthroline Preparation Products And Raw materials
Preparation ProductsAcetamide, 2-iodo-N-1,10-phenanthrolin-5-yl-
1,7-PHENANTHROLINE tris(5-nitro-1,10-phenanthroline-n1,n19)-iron(2++sulfate(1:1 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID 2-Nitrobenzyl alcohol o-Phenanthroline 3-Nitroacetophenone 2-NITRO-4-METHYLSULFONYLTOLUENE 5-NITRO-1,10-PHENANTHROLINE FERROUS PERCHLORATE,tris(5-nitro-1,10-phenanthroline-n1,n19)-iron(2++diperchlorat 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID MONOHYDRATE 1,10-Phenanthroline hydrate Nitrazepam Phenanthrene 5-NITRO-1,10-PHENANTHROLINE-2,9-DICARBOXYLIC ACID MONOHYDRAT Ferrous sulfate heptahydrate 3-METHYLADENINE 5-Nitro-1,10-phenanthroline 2-Nitrobenzoic acid Nitroethane

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