ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic acids 4'-Methylbiphenyl-2-carboxylic acid

4'-Methylbiphenyl-2-carboxylic acid

4'-Methylbiphenyl-2-carboxylic acid Basic information
Product Name:4'-Methylbiphenyl-2-carboxylic acid
Synonyms:4'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;2-(4-Methylphenyl)benzoic Acid 4'-Methylbiphenyl-2-carboxylic Acid;2-Carboxy-4'-methylbiphenyl, 2-(4-Methylphenyl)benzoic acid, 2-(p-Tolyl)benzoic acid;2-(p-Tolyl)benzoic Acid;1’-biphenyl]-2-carboxylicacid,4’-methyl-[;RARECHEM AL BO 0764;4'-Methyl-2-carboxybiphenyl;o-Tolylbenzoic acid
CAS:7148-03-0
MF:C14H12O2
MW:212.24
EINECS:230-462-0
Product Categories:Organic acids;Hypertension;Biphenyl & Diphenyl ether;INTERMEDIATESOF;C13 to C42+;Carbonyl Compounds;Carboxylic Acids;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
Mol File:7148-03-0.mol
4'-Methylbiphenyl-2-carboxylic acid Structure
4'-Methylbiphenyl-2-carboxylic acid Chemical Properties
Melting point 146-148°C
Boiling point 354.5±11.0 °C(Predicted)
density 1.156±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO, Methanol
pka3.90±0.36(Predicted)
form Solid
color White
CAS DataBase Reference7148-03-0(CAS DataBase Reference)
EPA Substance Registry System[1,1'-Biphenyl]-2-carboxylic acid, 4'-methyl- (7148-03-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
Hazard Note Irritant
HS Code 29163990
MSDS Information
4'-Methylbiphenyl-2-carboxylic acid Usage And Synthesis
Chemical PropertiesLight yellow solid
Uses4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives.
General Description4′-Methyl-2-biphenylcarboxylic acid (4′-Methyl-bi-phenyl-2-carboxyl-ic acid) can be synthesized by reacting 4′-methylbiphenyl-2-carbonitrile with methanol and 30% NaOH solution. Its crystal structure has been characterized by the centrosymmetric hydrogen-bonded dimers.
Purification MethodsCrystallise the acid from toluene or *C6H6 (m 147-148o). [Beilstein 9 H 677, 9 IV 2523.]
4'-Methylbiphenyl-2-carboxylic acid Preparation Products And Raw materials
Preparation ProductsMethyl 4'-methylbiphenyl-2-carboxylate-->4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID
6-(2'-CARBOXYPHENYL)-3-DIMETHYLAMINO-9-DIMETHYLAMINO-3H-XANTHYLIUM PERCHLORATE 4'-CYANO-BIPHENYL-2-CARBOXYLIC ACID Methyl Bifendate 4'-FLUORO-3'-METHYLBIPHENYL-4-CARBOXYLIC ACID 4'-METHOXY-3'-METHYLBIPHENYL-3-CARBOXYLIC ACID RARECHEM FH SE 0018 4'-METHYLBIPHENYL-2-CARBOXYLIC ACID METHYL ESTER,4'-Methylbiphenyl-2-carboxylic acid methyl ester 4'-FLUORO-3'-METHYLBIPHENYL-3-CARBOXYLIC ACID O-(3-BROMO-P-TOLUYL)BENZOIC ACID 3',4'-DIMETHYL-BIPHENYL-2-CARBOXYLIC ACID 4-Phenyltoluene 4'-FORMYL-BIPHENYL-2-CARBOXYLIC ACID CARBOXYLIC ACID 6-((2'-Carboxybiphenyl-4-yl)methyl)-7-hydroxy-5-propylpyrazolo(1,5-a)pyrimidine 2'-METHYLBIPHENYL-4-CARBOXYLIC ACID 3'-FLUORO-4'-METHYLBIPHENYL-4-CARBOXYLIC ACID 4'-Methylbiphenyl-2-carboxylic acid
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