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| | D-Glucurone Basic information |
| | D-Glucurone Chemical Properties |
| Melting point | 172-175 °C (lit.) | | alpha | 19 º (c=10, H2O) | | Boiling point | 227.71°C (rough estimate) | | density | 1,76 g/cm3 | | refractive index | 18.5 ° (C=5, H2O) | | storage temp. | Store below +30°C. | | solubility | water: soluble25mg/mL, clear, colorless | | pka | 11.96±0.60(Predicted) | | form | Crystals or Crystalline Powder | | color | White | | Odor | at 100.00 %. very mild mentholic | | Odor Type | mentholic | | optical activity | [α]24/D +18.8°, c = 8 in H2O | | Water Solubility | SOLUBLE | | Merck | 14,4467 | | BRN | 83595 | | InChIKey | OGLCQHRZUSEXNB-IEPORWDDSA-N | | LogP | -3.457 (est) | | CAS DataBase Reference | 32449-92-6(CAS DataBase Reference) | | EPA Substance Registry System | D-Glucuronolactone (32449-92-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25-36-26 | | WGK Germany | 2 | | RTECS | LZ8930000 | | TSCA | Yes | | HS Code | 29322980 |
| | D-Glucurone Usage And Synthesis |
| Chemical Properties | white crystals or crystalline powder | | Uses | D-Glucurone is a glucuronic acid derivative. It is used for treating canine hepatitis.
| | Uses | D-Glucurono-6,3-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis. It is utilized in the studies such as starting regent in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000, synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. | | Definition | The γ-lactone of glucuronic acid. Found in plant gums and animal connective tissues. | | General Description | D-(+)-Glucuronic acid γ-lactone (Glucourono-γ-lactone, Glucurone or Glycurone) is a carbohydrate derivative. It converted into L-ascorbic acid in animals and human body. Its molecule contains two five-membered rings. Its crystal structure has been studied. | | Purification Methods | Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.] |
| | D-Glucurone Preparation Products And Raw materials |
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