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L-Arginine hydrochloride

L-Arginine hydrochloride Basic information
Product Name:L-Arginine hydrochloride
Synonyms:argininemonohydrochloride;argivene;minophagena;monohydrochloride,l-arginin;r-gene;2-amino-5-guanidinovaleric acid monohydrochloride;L(+)-Arginine hydrochloride;ARGININE HYDROCHLORID
CAS:1119-34-2
MF:C6H15ClN4O2
MW:210.66
EINECS:214-275-1
Product Categories:Nutritional Supplements;L-Amino Acids;alpha-Amino Acids;Amino Acids;Biochemistry;for Resolution of Acids;chiral;Amino Acid Derivatives;Amino Acids 13C, 2H, 15N;Optical Resolution;Synthetic Organic Chemistry;Amino Acids;Amino Acids, Peptides and Proteins;Life Sciences Standards;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;PRILOSEC;amino;1119-34-2
Mol File:1119-34-2.mol
L-Arginine hydrochloride Structure
L-Arginine hydrochloride Chemical Properties
Melting point 226-230 °C(lit.)
alpha 22 º (c=8,6N HCl)
Boiling point 235℃[at 101 325 Pa]
density 1.42
vapor pressure <1 Pa (20 °C)
FEMA 3819 | L-ARGININE
storage temp. 2-8°C
solubility H2O: 100 mg/mL
form powder
pka1[at 20 ℃]
color white
PH5.5-7.0 (25℃, 1M in H2O)
PH Range5.5 - 7
Odorodorless
optical activity[α]20/D +22.0±0.5°, c = 5% in 5 M HCl
Water Solubility Soluble in water. Slightly soluble in hot alcohol.
λmaxλ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Sensitive Hygroscopic
Merck 14,780
BRN 3631658
Stability:Stable. Incompatible with strong oxidizing agents.
LogP-8.5--3.24 at 25℃
CAS DataBase Reference1119-34-2(CAS DataBase Reference)
EPA Substance Registry SystemL-Arginine, monohydrochloride (1119-34-2)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 37-36/38-36/37/38-20/21/22
Safety Statements 37/39-26-24/25-36
WGK Germany 2
RTECS CF1995500
F 3-10
TSCA Yes
HS Code 29252000
ToxicityLD50 orally in Rabbit: 12000 mg/kg
MSDS Information
ProviderLanguage
2-Amino-5-guanidinovaleric acid monohydrochloride English
SigmaAldrich English
ACROS English
ALFA English
L-Arginine hydrochloride Usage And Synthesis
Chemical PropertiesWhite crystalline powder
Usesgastric acid depressant
UsesAn essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).
UsesL-Arginine monohydrochloride is used in the treatment of heart and circulatory diseases. It is a precursor of nitric oxide synthesis that induces vasodilation in vivo, there by relaxing blood vessels. It is also used in the treatment of angina and other cardiovascular problems. It is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes. It is commonly used in cell culture media and drug development.
DefinitionChEBI: Arginine hydrochloride is a L-alpha-amino acid.
Brand nameR-Gene 10 (Pharmacia & Upjohn).
Biochem/physiol ActionsL-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.
Safety ProfileModerately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Purification MethodsA likely impurity is ornithine. Crystallise the salt from H2O at pH 5-7, by adding EtOH to 80% (v/v). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 2649.]
L-Arginine hydrochloride Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Activated carbon-->Gelatin-->L(+)-Arginine
Preparation ProductsL-(+)-Glutamic acid hydrochloride
L-ARGININE HCL (1,2-13C2) Ethyl N-benzoyl-L-argininate hydrochloride (P-CHLORO-PHE5,8)-BRADYKININ N'-Nitro-L-arginine L-ARGININE HCL (U-15N4) TIMTEC-BB SBB003441 Methyl L-argininate dihydrochloride L-BAME ARGININE-B-NAPHTHYLAMIDE HYDROCHLORIDE L-ARGININE HCL (GUANIDO-15N2) H-ARG-OME HCL Cbz-L-arginine hydrochloride N-BOC-L-Arginine hydrochloride L-ARGININE HCL (D7) L-ARGININE HCL (U-13C6) L-Arginine ethyl ester dihydrochloride BOC-D-ARG(TOS)-OH ETOAC L-Arginine hydrochloride
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