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| | Nebivolol hydrochloride Basic information |
| | Nebivolol hydrochloride Chemical Properties |
| Melting point | 220-222°C | | storage temp. | room temp | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | white to off-white | | Merck | 14,6432 |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | 3077 | | WGK Germany | 3 | | HS Code | 29322090 |
| | Nebivolol hydrochloride Usage And Synthesis |
| Chemical Properties | White to Off-White Powder | | Uses | Nebivolol selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM
| | Uses | A ?-Adrenergic blocker. Used as an antihypertensive | | Uses | Nebivolol Hydrochloride is a highly selective β1-adrenoceptor antagonist. | | Definition | ChEBI: (R,S,S,S)-nebivolol hydrochloride is a hydrochloride obtained by reaction of (R,S,S,S)-nebivolol with one equivalent of hydrochloric acid. It contains a (R,S,S,S)-nebivolol(1+). It is an enantiomer of a (S,R,R,R)-nebivolol hydrochloride. | | Biological Activity | Highly selective β 1 -adrenoceptor antagonist (K i values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at β 1 , 5-HT 1A , β 2 , 5-HT 2 , α 1 , H 1 and D 2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC 50 = 11.36 μ M in renal arteries) and displays antihypertensive activity in vivo . | | Biochem/physiol Actions | Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods. | | storage | Desiccate at RT |
| | Nebivolol hydrochloride Preparation Products And Raw materials |
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