(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE

(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Basic information
Product Name:(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE
Synonyms:N-isocyaniminotriphenylphosphorane;Nsc371099;(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE;1-methylidyne-2-(triphenyl-lambda~5~-phosphanylidene)diazanium;(N-Isocyanoimino)triphenylphosphorane 95%;(N-Isocyanoimino)Triphenylphosphorane;(N-Isocyanoi;(Isocyanoimino)triphenylphosphorane>
CAS:73789-56-7
MF:C19H15N2P
MW:302.309561
EINECS:
Product Categories:
Mol File:73789-56-7.mol
(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Structure
(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Chemical Properties
Melting point 160-161 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form solid
color White to Light yellow to Light orange
Safety Information
HS Code 29319090
MSDS Information
(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Usage And Synthesis
UsesDespite growing interest for therapeutic and other biological applications, cyclic peptidomimetics are challenging to synthesize. As reported by the lab of Andrei Yudin, (N-isocyanoimino)triphenylphosphorane (Pinc
) enables zwitterionic-controlled generation of peptide macrocyles from linear peptides and aldehydes. Containing a 1,3,4-oxadiazole, the resulting peptide exhibits both improved membrane permeability, lipophilicity, and aqueous solubility.
Different functional groups can be introduced by varying the aldehyde, and initial work used propionaldehyde (538124), phenylacetaldehyde (107395), and isovaleraldehyde (146455).

(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Preparation Products And Raw materials
Preparation Products2-(4-bromophenyl)-1,3,4-oxadiazole-->3-(m-Tolyl)-1H-pyrazole-->2-Propynenitrile, 3-phenyl- (9CI)-->2-(3-Methylphenyl)-1,3,4-oxadiazole-->1,3,4-Oxadiazole, 2-[1,1'-biphenyl]-4-yl--->2-(3-bromophenyl)-1,3,4-oxadiazole-->2-(3-Fluoro-phenyl)-[1,3,4]oxadiazole
(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE

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