|
| | L-CYCLOSERINE Basic information |
| Product Name: | L-CYCLOSERINE | | Synonyms: | (S)-4-Aminoisoxazolidin-3-one;Levocycloserine;L-Cycloserine,99%;L-Cycloserine,(S)-4-Amino-3-isoxazolidone;cycloserinr;102.09;Cycloserine Impurity 4 (L-Cycloserine);Cycloserine Impurity 4 | | CAS: | 339-72-0 | | MF: | C3H6N2O2 | | MW: | 102.09 | | EINECS: | 206-427-0 | | Product Categories: | NOVASTAT-W;VARIOUSAMINE | | Mol File: | 339-72-0.mol |  |
| | L-CYCLOSERINE Chemical Properties |
| Melting point | 147 °C | | Boiling point | 191.38°C (rough estimate) | | density | 1.278 | | refractive index | 1.5110 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | H2O: soluble50mg/mg protein | | pka | 14.36±0.40(Predicted) | | form | White to off-white powder. | | color | White to Off-White | | BRN | 80799 | | CAS DataBase Reference | 339-72-0(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 5-20 | | Safety Statements | 38-36/37 | | WGK Germany | 2 | | RTECS | NY2976000 | | F | 10 |
| | L-CYCLOSERINE Usage And Synthesis |
| Chemical Properties | WHITE GRANULAR POWDER | | Uses | antibacterial, coccidiostat | | Uses | L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase. | | Definition | ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora. | | Biochem/physiol Actions | L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis. | | Purification Methods | Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.] |
| | L-CYCLOSERINE Preparation Products And Raw materials |
|
