4-Chlorophenol

4-Chlorophenol Chemical Properties
Melting point 42-45 °C
Boiling point 220 °C (lit.)
density 1.306 g/mL at 25 °C (lit.)
vapor density 4.43 (vs air)
vapor pressure 1 mm Hg ( 49.8 °C)
refractive index 1.5579
Fp 240 °F
storage temp. 2-8°C
solubility ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
form Low Melting Crystalline Mass
pka9.18(at 25℃)
color White to pale yellow
OdorPhenolic
Odor Threshold30 ppm
Water Solubility 2.7 g/100 mL (20 ºC)
Sensitive Air Sensitive
Merck 14,2154
BRN 507004
Stability:Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.
LogP2.5 at 35℃
CAS DataBase Reference106-48-9(CAS DataBase Reference)
NIST Chemistry Referencep-Chlorophenol(106-48-9)
EPA Substance Registry Systemp-Chlorophenol (106-48-9)
Safety Information
Hazard Codes Xn,N
Risk Statements 20/21/22-51/53-50
Safety Statements 28-61-28A-24/25-60-36/37
RIDADR UN 2020 6.1/PG 3
WGK Germany 2
RTECS SK2800000
10-23
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29081000
Hazardous Substances Data106-48-9(Hazardous Substances Data)
ToxicityLD50 orally in rats: 0.67 g/kg (Deichmann)
MSDS Information
ProviderLanguage
4-Chlorophenol English
ACROS English
SigmaAldrich English
ALFA English
4-Chlorophenol Usage And Synthesis
Chemical Propertiesoff-white to light tan crystals or powder
Chemical PropertiesAll isomers have a characteristic odor.
UsesIntermediates of Liquid Crystals
Usesantineoplastic
UsesBiocide; disinfectant for home, hospital and farm.
UsesIt is used as main raw material of compounding for medicine, dye, plastic and other industries. 4-Chlorophenol was used in visible-light-induced degradation of 4-chlorophenol in aqueous suspension of pure TiO2.
DefinitionChEBI: A monochlorophenol substituted at the pare position by a chlorine atom.
Synthesis Reference(s)The Journal of Organic Chemistry, 50, p. 2145, 1985 DOI: 10.1021/jo00212a029
Tetrahedron Letters, 24, p. 3117, 1983 DOI: 10.1016/S0040-4039(00)88111-3
General DescriptionWhite crystals with a strong phenol odor Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.
Air & Water ReactionsSlightly soluble to soluble in water.
Reactivity ProfileCHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 108°F.
HazardToxic by skin absorption, inhalation, or ingestion; strong irritant to tissue.
Health HazardInhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation.
Fire HazardSpecial Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires.
Flammability and ExplosibilityNotclassified
Safety ProfilePoison by inhalation and intraperitoneal routes. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe skin and eye irritant. Human systemic effects by inhalation: excitement, irritability. Mutation data reported. Combustible when exposed to heat or flame. To fight fire, use water, spray, mist, fog, foam, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS and CHLORIDES.
Potential ExposureMonochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.
ShippingUN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification MethodsDistil the phenol, then crystallise it from pet ether (b 40-60o) or hexane, and dry it under vacuum over P2O5 at room temperature. [Bernasconi & Paschalis J Am Chem Soc 108 2969 1986, Beilstein 6 IV 820.]
IncompatibilitiesMay form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.
Waste DisposalIncinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.
1-(2-BROMOETHOXY)-4-CHLOROBENZENE 4-Chlorostyrene 4-Chlorophenol methyl ether,4-Chlorophenol methyl ether 3,4-Dichlorophenol TETRACHLOROCATECHOL CARBONIC ACID TERT-BUTYL 2,4,5-TRICHLOROPHENYL ESTER 2,3,4-TRICHLOROPHENOL Pentachlorophenol sodium salt hydrate 2,4,6-TRICHLOROANISOLE 2,4,5-Trichlorophenol 2,4,6-Trichlorophenol 2,3,4-TRICHLOROANISOLE 4-CHLOROPHENOXYACETYL CHLORIDE Hexachlorophene Pentachlorophenol ALPHA,4-DICHLOROANISOLE 4-Chlorophenol 4-CHLOROPHENYL CHLOROFORMATE

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.