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| | p-Acetylamino benzoic acid Basic information |
| | p-Acetylamino benzoic acid Chemical Properties |
| Melting point | 259-262 °C (dec.)(lit.) | | Boiling point | 311.69°C (rough estimate) | | density | 1.2822 (rough estimate) | | refractive index | 1.5600 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Powder | | pka | pK1: 4.28 (25°C) | | color | Off-white to slightly beige | | Water Solubility | <0.1 g/100 mL at 21 ºC | | BRN | 390602 | | Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. | | CAS DataBase Reference | 556-08-1(CAS DataBase Reference) | | NIST Chemistry Reference | N-(4-Carboxyphenyl)acetic acid amide(556-08-1) | | EPA Substance Registry System | Benzoic acid, 4-(acetylamino)- (556-08-1) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29242995 |
| | p-Acetylamino benzoic acid Usage And Synthesis |
| Chemical Properties | white or off-white powder or crystals | | Originator | 4-Acetamidobenzoic acid ,ARIAC | | Uses | Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970). | | Uses | immune stimulant (component) | | Definition | ChEBI: A amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4. | | Manufacturing Process | Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air
condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of
MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated
solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0
g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture
allow to stand for 6 h and stirring was continue till the solution became
colorless. Hot solution was filtered and filtrate treated hydrochloric acid to
slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was
obtained as white precipitate, melting point 250°C. | | Therapeutic Function | Antiviral | | General Description | Needles or off-white powder. | | Air & Water Reactions | Water insoluble. | | Reactivity Profile | Simultaneously an amide and a carboxylic acid. | | Fire Hazard | Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible. |
| | p-Acetylamino benzoic acid Preparation Products And Raw materials |
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