EOSIN

EOSIN Basic information
Product Name:EOSIN
Synonyms:disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate;waterred2;Eosin Disodium;AKA230(1);AKA230(2);RED 21 LAKE;EOSIN Y, INDICATOR GRADE;EOSIN Y, 5 WT. % SOLUTION IN WATER
CAS:17372-87-1
MF:C20H6Br4Na2O5
MW:691.85418
EINECS:241-409-6
Product Categories:Inhibitors;Fluorescent;Dyes and Pigments;Organics;M;Xanthene;Stains and Dyes;Stains&Dyes, A to;Hematology and Histology;Hematology Stains;Fluorescent Labels;Fluorescent Probes, Labels, Particles and Stains;Other Fluorescent Labels
Mol File:17372-87-1.mol
EOSIN Structure
EOSIN Chemical Properties
Melting point >300°C
density 1.02 g/mL at 20 °C
vapor pressure 0Pa at 25℃
Fp 11 °C
storage temp. Store at RT.
solubility H2O: 0.1 g/mL, dark red
Colour Index 45380
pka2.9, 4.5(at 25℃)
form Solid
color Reddish
PH9.2 (10g/l, H2O, 20℃)
PH Range0(yellow)-3(green fluoresc.)
Water Solubility freely soluble
λmax514nm
Merck 14,3603
BRN 3586809
Stability:Stable. Incompatible with strong oxidizing agents.
Biological ApplicationsTreating age-related macular degeneration,burns,cancer,diabetes,obesity,dental bone defects,gastroesophageal reflux disease,prostate cancer,viral diseases; stents; wound-healing materials
Major ApplicationPhotovoltaic devices, color filter, nanoscale host material, detection of latent fingerprints, inks, detergents, hair dyes, cosmetics, implantable drug delivery devices, stents, diagnosis of breast lesions, labeling nucleic acids, detecting proteins, stress biomarkers, phosphoprotein, breast cancer metastases, antimicrobial agent, treatment of burns, endodontic, diabetes, obesity, cancer, radiochemotherapy, DNA sequencing, gene expression profiling, wound healing promoters
LogP-1.33
CAS DataBase Reference17372-87-1(CAS DataBase Reference)
EPA Substance Registry SystemEosin Yellowish (YS) (17372-87-1)
Safety Information
Hazard Codes F,T,Xn,Xi
Risk Statements 11-23/24/25-39/23/24/25-52/53-41-22-36-10
Safety Statements 7-16-36/37-45-24/25-61-39-26
RIDADR UN 1230 3/PG 2
WGK Germany 1
RTECS LM5850000
TSCA Yes
HS Code 32041200
ToxicityLD50 orally in Rabbit: > 2000 mg/kg
MSDS Information
ProviderLanguage
C.I. 45380 English
ACROS English
SigmaAldrich English
EOSIN Usage And Synthesis
Chemical Propertiesbrownish-red powder
UsesEosin is most often used as a counterstain to haematoxylin in H&E (haematoxylin and eosin) staining. H&E staining is one of the most commonly used techniques in histology.
UsesAnti Septic
UsesEosin Yellowish noted to reduce the affinity of Mg2+-ATPase for ATP and increase the enzyme affinity for Mg2+ at concentrations of 10-50 ?M. At higher concentrations near 100 ?M the affinity for Mg2+-ATPase for the ion-activator has been shown to be reduced. This compound has also been reported to be a photosensitizer that works as a molecular photoelectrode via catalyzation of the visible-light-driven electron-transfer reaction. Eosin Y is also used to stain structures such as muscle, cytoplasm, and collagen. This agent also enhances fluorescent quenching abilities by forming a complex with polyvinulpyrrolidone.
Preparationcountries called red. Fluorescent element (C.I. Acid Yellow 73, C.I. 45350) in water or ethanol solution bromine into four bromine derivatives, and then into sodium salt.
DefinitionChEBI: An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.
Flammability and ExplosibilityNotclassified
Biological Activityami5/eosin y disodium salt is a non-selective protein methyltransferase inhibitor.post-translational protein methylation at lysine and arginine residues is related to the gene expression regulation. the enzymatic activities of protein methyltransferases serve to do covalent modifications in the control of gene transcription.
Safety ProfilePoison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of Brand NazO. See also BROMIDES.
in vitroami5/eosin y disodium salt has been identified as a competitive inhibitor of sam binding and had been shown to inhibit not only prmts but also lysine methylation by the set7 and disruptor of telomeric silencing 1-like (dot1l) mtases in vitro. both ami5/eosin y disodium salt and its analog ami-1 have been used as lead compounds for the development of novel mtase-specific inhibitors. moreover, it was found that ami5/eosin y disodium salt could inhibit set7 in vitro and decrease h3k4m1 in vascular endothelial cells. [1].
IC 500.78 and 1.41 μm for hmt1p and prmt1, respectively
storage+4°C
Properties and Applicationsyellow peach. Orange powder, soluble in water and ethanol with fluorescent blue light is yellowish red solution. Meet strong sulfuric acid yellow, it will be diluted yellow light red precipitate generated. Dyeing copper ions in the blue colour and lustre; Iron ion colour and lustre in the dark blue. Discharge the gender is good. Mainly used in red ink and red pencils, only comfortable carpet dyeing. After refining can be used as medicine and cosmetics of coloring. Can also be used in leather dyeing. The aluminum salt can be used as organic pigments.
Standard Light Fastness Soaping Persperation Fastness Oxygen bleaching Fastness to seawater
Fading Stain Fading Stain Fading Stain
ISO 2 3 3 2 1 2 2 2
AATCC 1 2 2 3 1 1 3 3
Purification MethodsDissolve it in the minimum volume of H2O (1g/mL), filter and add EtOH until separation of salt is complete. Filter the solid off, wash it with absolute EtOH, then Et2O and dry it first in air, then at 100o. It is used for staining blood cells and for estimating traces of Ag. [Selsted & Becker Anal Biochem 155 270 1986, El-Ghamry & Frei Anal Chem 40 1986 1968.] [Beilstein 19 III/IV 2917.] [See above]
references[1] okabe j,fernandez az,ziemann m,keating st,balcerczyk a,el-osta a. endothelial transcriptome in response to pharmacological methyltransferase inhibition. chemmedchem.2014 aug;9(8):1755-62.
EOSIN Preparation Products And Raw materials
Raw materialsFluorescein Sodium
Preparation ProductsEOSIN METHYLENE-BLUE-->ETHYL EOSIN
Sodium benzoate Tetrachlorofluorescein FURFURYL ALCOHOL RESIN Denatonium Benzoate Anhydrous Ascoric Acid Carbofuran Stearic acid Folic acid SULFORHODAMINE B Tetrahydrofuran Fluorescein Methanol Styrene-acrylic latex EOSIN B Furazolidone Benzyl benzoate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Citric acid

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