ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Other Amino Acid Protection N-(9-Fluorenylmethoxycarbonyloxy)succinimide

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

N-(9-Fluorenylmethoxycarbonyloxy)succinimide Basic information
Product Name:N-(9-Fluorenylmethoxycarbonyloxy)succinimide
Synonyms:9-fluorenylmethoxycarbonyloxysuccinimide;N-(9-FluorenylmethoxyCarbonyloxy)Succinimide9-Fluorenylmethylsuccinimidylcarbonate;CARBONIC ACID 2,5-DIOXO-PYRROLIDIN-1-YL ESTER 9H-FLUOREN-9-YLMETHYL ESTER;CARBONIC ACID FLUORENYLMETHYL SUCCIN-N-YL-ESTER;FLUORENYLMETHYL SUCCINIMIDYL CARBONATE;9-FLUORENMETHYL SUCCINIMIDYL CARBONATE;9-FLUORENYLMETHOXYCARBONYL-N-HYDROXYSUCCINIMIDE;9-FLUORENYLMETHYL N-HYDROXYSUCCINIMIDYL CARBONATE
CAS:82911-69-1
MF:C19H15NO5
MW:337.33
EINECS:433-520-5
Product Categories:peptides;Medical Intermediates;Fluorenes, Flurenones;Benzocycles;Pyrrolidines;N-Protecting Reagents;Amino Acid Derivatives;Heterocycles;Miscellaneous Reagents;Biochemistry;Condensation & Active Esterification;Fluorenes;Fluorenes & Fluorenones;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Succinimides;Peptide Synthesis;Protective Reagents (Peptide Synthesis);Synthetic Organic Chemistry;Fmoc-Amino acid series;Fmoc-OSU;bc0001
Mol File:82911-69-1.mol
N-(9-Fluorenylmethoxycarbonyloxy)succinimide Structure
N-(9-Fluorenylmethoxycarbonyloxy)succinimide Chemical Properties
Melting point 150-153 °C(lit.)
Boiling point 150-153°C
density 1.3460 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. 2-8°C
solubility Soluble in dimethyl sulfoxide and dimethyl formamide.
form Microfine Powder
color White or almost white
Sensitive Moisture Sensitive
BRN 3569540
Stability:Moisture Sensitive
CAS DataBase Reference82911-69-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,N,Xn
Risk Statements 36/37/38-51/53-43-22
Safety Statements 22-24/25-26/37/39-26-61-37-24
RIDADR UN 3077 9 / PGIII
WGK Germany 3
F 10-21
Hazard Note Moisture Sensitive
HazardClass 9
HS Code 29251995
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
N-(9-Fluorenylmethoxycarbonyloxy)succinimide Usage And Synthesis
Chemical PropertiesWhite powder
UsesN-(9-Fluorenylmethoxycarbonyloxy)succinimide is used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.
UsesReagent for the preparation of pure Fmoc amino acids free from contamination by Fmoc-dipeptides.
UsesN-protecting reagent for oligonucleotide and peptide syntheses
Purification MethodsRecrystallise the carbonate from CHCl3/Et2O, or from pet ether (b 40-60o). [Pauet Can J Chem 60 976 1982, Lapatsaris et al. Synthesis 671 1983.]
N-(9-Fluorenylmethoxycarbonyloxy)succinimide Preparation Products And Raw materials
Preparation Products[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid-->FMOC-L-PROPARGYLGLYCINE-->FMOC-b-Ala-OH-->Fmoc-Leu-OH-->FMOC-D-PHG-OH-->Fmoc-L-4-Iodophenylalanine-->Fmoc-4-nitro-L-phenylalanine-->FMOC-L-Arginine-->Fmoc-Cys(tBu)-OH-->N-Boc-N'-Fmoc-L-Lysine-->Fmoc-L-hydroxyproline-->FMOC-(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC ACID-->Piperidine, 1-(9H-fluoren-9-ylmethyl)--->FMOC-2-(2-AMINOETHOXY)ETHANOL-->N-Fmoc-L-homoserine-->Nalpha-FMOC-L-Tryptophan-->FMOC-L-Methionine
N-Hydroxysuccinimide SUCCINAMIDE PHENETHYL FORMATE Barium carbonate Bismaleimide Carbonate N-METHOXY-N-METHYL-PROPIONAMIDE N-methyl acetohydroxamic acid Fmoc-Aib-OH Succinimide DIALIFOS AMMONIUM CARBONATE N-Methoxy-N-methylacetamide N-(9-FLUORENYLMETHOXYCARBONYLOXY) SUCCINIMIDE = FMOC-OSU N-METHOXYDIACETAMIDE Fmoc 9-Fluorenemethanol Zinc carbonate
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