5-Methylsalicylic acid

5-Methylsalicylic acid Basic information
Product Name:5-Methylsalicylic acid
Synonyms:2,5-Cresotic acid;2,5-cresoticacid;2-hydroxy-5-methyl-benzoicaci;6-Hydroxy-3-methylbenzoic acid;alpha-Cresotinic acid;alpha-cresotinicacid;Benzoic acid, 2-hydroxy-5-methyl-;p-Cresotinic acid
CAS:89-56-5
MF:C8H8O3
MW:152.15
EINECS:201-918-6
Product Categories:Indolines ,Indoles ,Indazoles;Organic acids;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatics
Mol File:89-56-5.mol
5-Methylsalicylic acid Structure
5-Methylsalicylic acid Chemical Properties
Melting point 150-154 °C (lit.)
Boiling point 234.6°C (rough estimate)
density 1.2143 (rough estimate)
refractive index 1.4945 (estimate)
storage temp. Sealed in dry,Room Temperature
pkapK1:4.08 (25°C)
form Powder
color White to beige
Water Solubility 21.9g/L(100 ºC)
Merck 14,2582
BRN 1909076
CAS DataBase Reference89-56-5(CAS DataBase Reference)
NIST Chemistry Reference5-Methylsalicylic acid(89-56-5)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-37/38-41-36/37/38
Safety Statements 26-36/39-22-36
WGK Germany 3
RTECS GP3920200
HS Code 29182110
MSDS Information
ProviderLanguage
2-Hydroxy-5-methylbenzoic acid English
SigmaAldrich English
ACROS English
ALFA English
5-Methylsalicylic acid Usage And Synthesis
Chemical Properties5-Methylsalicylic acid is a white to beige powder that is soluble in basic water and in polar organic solvents. At neutral pH, the acid exists as 5-methylsalicylate Its functional groups include a carboxylic acid and a phenol group. It is one of four isomers of methylsalicylic acid.
UsesToxicity is similar to salicylic acid. 5-Methylsalicylic acid is used in manufacturing of dyes.
Uses5-Methylsalicylic acid was used in generation of o-sulfate conjugates in situ and their analysis by ultra-performance liquid chromatography-time-of-flight mass spectrometry.
Preparation5-Methylsalicylic acid can be prepared by hydroxylation of 3-methylbenzoic acid.
General Description5-Methylsalicylic acid exhibits a significant cross-reactivity during fluorescent polarization immunoassay for salicylates in serum.
Purification MethodsCrystallise the acid from H2O. [Beilstein 10 H 227, 10 II 134, 10 III 516, 10 IV 610.]
5-Methylsalicylic acid Preparation Products And Raw materials
Preparation Products5-Methylsalicylamide-->METHYL 5-AMINOSALICYLATE-->2-(acetyloxy)-5-methylbenzoic acid-->7-Benzofurancarbonylchloride,2,3-dihydro-5-methyl-(6CI,9CI)-->METHYL 2-METHOXY-5-METHYLBENZOATE 97-->2-ethoxy-5-methylbenzoic acid
NAPHTHOCHROME GREEN 3-TERT-BUTYL-6-METHYLSALICYLIC ACID 3-METHYLSALICYLIC ACID SODIUM SALT,3-METHYLSALICYLIC ACID SODIUM SALT 97+% 5,5'-[4-(dimethylamino)benzylidene]bis(3-methylsalicylic) acid 5-[(3-carboxy-5-methyl-4-oxo-2,5-cyclohexadien-1-ylidene)[4-[(4-tolyl)amino]phenyl]methyl]-3-methylsalicylic acid Ethyl 2-(Chlorosulfonyl)acetate 2'-Hydroxy-3-phenylpropiophenone 3,5-bis[[[2-[[2-(dodecylamino)ethyl]amino]ethyl]amino]methyl]-4-hydroxybenzoic acid 6-METHYLSALICYLIC ACID 6-METHYLSALICYLIC ACID ETHYL ESTER 95+%,6-METHYLSALICYLIC ACID ETHYL ESTER 3-Hydroxybenzoic acid 4-Trifluoromethylsalicylic acid ethyl 5-acetyl-2-benzyloxybenzoate 5-Formylsalicylic acid 3-[(Dimethylamino)methyl]-4-hydroxybenzoic acid methyl ester 3,5-Dihydroxybenzoic acid phosphoric acid CHLOROPHOSPHONAZO III

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