3,5-Dichloroaniline

3,5-Dichloroaniline Basic information
Product Name:3,5-Dichloroaniline
Synonyms:3,5-DCA;Phloroglucinol Impurity 26;3,5-dichloro;3,5-dichloro-anilin;3,5-dichloro-benzenamin;Aniline, 3,5-dichloro-;Benzenamine,3,5-dichloro-;BF352-31
CAS:626-43-7
MF:C6H5Cl2N
MW:162.02
EINECS:210-948-9
Product Categories:Anilines, Aromatic Amines and Nitro Compounds;Amines;C2 to C6;Nitrogen Compounds;Alpha sort;AromaticsPesticides&Metabolites;Chemical Class;D;DAlphabetic;DIA - DIC
Mol File:626-43-7.mol
3,5-Dichloroaniline Structure
3,5-Dichloroaniline Chemical Properties
Melting point 46-52 °C (lit.)
Boiling point 259-260 °C/741 mmHg (lit.)
density 1.58
refractive index 1.6000 (estimate)
Fp >230 °F
storage temp. Store below +30°C.
solubility 0.78g/l
pkapK1:2.37(+1) (25°C)
form crystalline
color dark gray
Water Solubility 0.6 g/L (26 ºC)
BRN 636492
LogP2.9 at 20-25℃
CAS DataBase Reference626-43-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 3,5-dichloro-(626-43-7)
EPA Substance Registry System3,5-Dichloroaniline (626-43-7)
Safety Information
Hazard Codes T,N,Xi
Risk Statements 23/24/25-33-50/53
Safety Statements 28-36/37-45-60-61-28A
RIDADR UN 3442 6.1/PG 2
WGK Germany 3
8
Hazard Note Irritant
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29214210
Hazardous Substances Data626-43-7(Hazardous Substances Data)
MSDS Information
ProviderLanguage
3,5-Dichloroaniline English
SigmaAldrich English
ACROS English
ALFA English
3,5-Dichloroaniline Usage And Synthesis
Chemical Propertieswhite to brown crystals or needle crystal, soluble in ethanol, ether, diethyl carbonate, insoluble in water, high toxicity, corrosive.
UsesDichlorobenzenamine is used in the synthesis of effective inhibitors of plant δ1-pyrroline-4-carboxylate reductase. Also used in the preparation of anti-tumor agents based upon diaryl urea derivatives.
Application3,5-Dichloroaniline is used in the production of pesticides, dyes and pharmaceuticals. 3,5-Dichloroaniline is an intermediate in the production of fungicides fumonisin, isoxaflutole, vinblastine and myclobutanil.
Preparationsynthesis of 3,5-Dichloroaniline: Add 25% hydrochloric acid and o-nitroaniline in the reaction kettle, turn on the stirring, pass chlorine gas for chlorination at 10-20℃ and negative pressure, after passing chlorine gas, continue to stir for 15min, then filter, and wash the filter cake with water to neutral, that is, 2,4-dichloro-6-nitroaniline.
In another reaction kettle add industrial ethanol, under stirring, then add 2,4-dichloro-6-nitroaniline, add 95% H2SO4 below 40°C, cool to 15°C, add sodium nitrite in batches, after adding sodium nitrite, continue to hold the reaction at 15°C for 4h, then put the material into denitration kettle, slowly heat to reflux temperature 80°C and keep reflux for 2h, then raise the temperature to evaporate ethanol, and then distill the ethanol. Liquid material into the distillation kettle for water distillation, distillation of the resulting oil and water material for stratification, to obtain 3,5-dichloronitrobenzene.
Put a certain amount of water and 3,5-dichloronitrobenzene in the reaction kettle, raise the temperature to reflux under stirring, add a certain concentration of sodium disulfide solution drop by drop in 1h, and keep reflux for 3h, rest stratification, the lower layer of oily material washed with hot water to obtain 3,5-dichloroaniline.
DefinitionChEBI: 3,5-dichloroaniline is a dichloroaniline.
2,6-Dichloro-4-nitrophenol 2,4-DICHLORO-6-NITROANILINE 2,3,5,6-TETRACHLOROANILINE Pentachloroaniline DICHLORPHENAMIDE BULK POWDER N-(4-amino-2,6-dichloro-phenyl)acetamide 3,4-Dichloroaniline 3,5-Dichloronitrobenzene 2,3,4,5-Tetrachloronitrobenzene 2,4-Dichloroaniline 4-Chloroaniline 3,5-Dichlorophenyl isocyanate 2-Chloroaniline 2,3-Dichloroaniline 2,5-Dichloroaniline 3,5-Dichloroaniline 3-Chloroaniline 2,6-Dichloroaniline

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.