Triethylamine trihydrofluoride

Triethylamine trihydrofluoride Basic information
Application
Product Name:Triethylamine trihydrofluoride
Synonyms:HF 37% IN TRIETHYLAMINE;HF;HYDROGEN FLUORIDE TRIETHYLAMINE;MEC-82;TRIETHYLAMINE TRIHYDROFLUORIDE;TRIETHYLAMINE TRISHYDROFLUORIDE;TRIETHYLAMINE TRIS(HYDROGEN FLUORIDE);Triethylamin-trihydrofluoride
CAS:73602-61-6
MF:C6H18F3N
MW:161.21
EINECS:277-550-5
Product Categories:Fluorinating Reagents;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Fluorination;Halogenation;Nucleophilic Fluorinating Reagents;Synthetic Organic Chemistry
Mol File:73602-61-6.mol
Triethylamine trihydrofluoride Structure
Triethylamine trihydrofluoride Chemical Properties
Melting point -29--27°C
Boiling point 70 °C15 mm Hg(lit.)
density 0.989 g/mL at 25 °C(lit.)
refractive index n20/D 1.3915(lit.)
Fp 190 °F
storage temp. Store below +30°C.
solubility soluble in Chloroform, Hexane
form Liquid
color Clear yellow to brown
Specific Gravity0.989
PH3 (H2O, 20℃)(saturated aqueous solution)
Water Solubility soluble
Sensitive Hygroscopic
BRN 5522945
Exposure limitsACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3
CAS DataBase Reference73602-61-6(CAS DataBase Reference)
EPA Substance Registry SystemEthanamine, N,N-diethyl-, trihydrofluoride (73602-61-6)
Safety Information
Hazard Codes T+,T,C,Xi,F
Risk Statements 26/27/28-35-36/37/38-20/21/22-11
Safety Statements 26-36/37/39-45-7/9-36/37-36-61-29-16-3
RIDADR UN 3265 8/PG 2
WGK Germany 3
Hazard Note Corrosive
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29211910
MSDS Information
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Triethylamine trihydrofluoride English
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Triethylamine trihydrofluoride Usage And Synthesis
Application

The t-butyldimethylsilyl (TBDMS) group is the most widely used 2'-OH protection in synthesis of oligoribonucleotides. The TBDMS-group became much used particularly after it was combined with phosphoroamidite methodology and was also the choice when H-phosphonate based RNA-synthesis was introduced. Removal of TBDMS-protection is most commonly done with 1 M tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF). These conditions has proven efficient.

Chemical Propertiesclear yellow liquid
UsesTriethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams.
UsesMild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.
General DescriptionTriethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.
Triethylamine trihydrofluoride Preparation Products And Raw materials
Preparation Products5-Methyluridine
BENZYLTRIETHYLAMMONIUM TETRAFLUOROBORATE Tetrabutylammonium tetrafluoroborate Trifluoperazine dihydrochloride TETRA-N-PROPYLAMMONIUM HEXAFLUOROARSENATE TETRAHEXYLAMMONIUM TETRAFLUOROBORATE (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE Perfluorotributylamine Tetraethylammonium hexafluorophosphate Perfluorotripropylamine tetrapropylammonium trifluoromethanesulphonate TETRAPROPYLAMMONIUM HEXAFLUOROPHOSPHATE Tetrabutylammonium triflate Tetraethylammonium tetrafluoroborate TETRAETHYLAMMONIUM TRIFLUOROMETHANESULFONATE Tetrabutylammonium hexafluorophosphate N-CYANO-N,N,N-TRIETHYLAMMONIUMTETRAFLUOR OBORATE Triethylamine trihydrofluoride PERFLUOROTRIHEXYLAMINE

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