2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER

2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Basic information
Product Name:2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER
Synonyms:SALOPHEN;ACETYL-P-AMINOPHENYLSALICYLATE;2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER;4-acetamidophenyl salicylate;acetaminosalol;p-Acetamidophenyl salicylate;Phenetsal;Asalphen
CAS:118-57-0
MF:C15H13NO4
MW:271.27
EINECS:204-261-3
Product Categories:
Mol File:118-57-0.mol
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Structure
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Chemical Properties
Melting point 187°
Stability:Stable. Incompatible with strong oxidizing agents.
LogP2.562 (est)
Safety Information
MSDS Information
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Usage And Synthesis
Chemical Propertiessolid
OriginatorAcetaminosal ,ZYF Pharm Chemical
UsesAnalgesic; antipyretic.
DefinitionChEBI: Acetaminosalol is a carbonyl compound.
Manufacturing Process2 Methods of producing of acetyl salicylic acid ester of N-acetyl-paminophenol:
1. 65.0 g of N-acetyl-p-aminophenol were slurried with 400 ml of water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the mixture with stirring, the temperature being maintained 10°-15°C. To the solution obtained, 75.0 g of acetyl salicylic chloride were added with vigorous stirring over a period of 0.5 h, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and adjusted to greater than 10 by the addition of a small amount of 20% sodium hydroxide. After all the acid chloride had been added, vigorous stirring was continued for 0.5 h during which time the crude product separated out. The acetyl salicylic acid ester of N-acetyl-p-aminophenol was filtered off, washed thoroughly with water and recrystallised from ethanol.
2. 65.0 g of sodium N-acetyl-p-aminophenol were slurried with 500.0 g of dry benzene and 80.0 g of acetyl salicylic chloride added. The mixture was heated under reflux for 4 h and filtered hot. The excess benzene was removed under vacuum and the crude acetyl salicylic acid ester of N-acetyl-p-aminophenol crystallized from ethanol.

Brand nameAcephen (G & W); Infants’ Feverall (Actavis); Injectapap (Ortho-McNeil); Neopap (Polymedica); Tylenol (McNeil).
Therapeutic FunctionAnalgesic, Antineuralgic, Antirheumatic, Antipyretic
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Preparation Products And Raw materials
Raw materialsAcetaminophen
ZINC ACEXAMATE (Z)-1-(4-METHOXYPHENYLIMINO)-4,4,6-TRIMETHYL-2-OXO-2,4-DIHYDRO-1H-PYRROLO[3,2,1-IJ]QUINOLIN-8-YL 2-METHOXYBENZOATE BENORILATE AKOS BBS-00006001 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER

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