Fast Green FCF

Fast Green FCF Basic information
Product Name:Fast Green FCF
Synonyms:1724green;MIDORI3;FAST GREEN FCF, CERTIFIED (C.I. 42053);FAST GREEN FCF CERTIFIED;FAST GREEN FCF C.I. 42053 FOR MICROSCOPICAL STAINING;FastGreenFcfForMicroscopyC.I.42053;FastGreenFcfForMicroscopy;FAST GREEN FCF C.I. No 42053
CAS:2353-45-9
MF:C37H37N2NaO10S3
MW:788.88
EINECS:219-091-5
Product Categories:Analytical Chemistry;Food Colors by Food Sanitation Law in Japan;Organics;Xanthene;marker
Mol File:2353-45-9.mol
Fast Green FCF Structure
Fast Green FCF Chemical Properties
Melting point 290 °C (dec.) (lit.)
Boiling point 260℃[at 101 325 Pa]
density 0.513[at 20℃]
vapor pressure 0Pa at 25℃
storage temp. room temp
solubility H2O: soluble50mg/mL, clear, colorless to faintly yellow
Colour Index 42053
form Powder/Solid
color Red to Red-Brown
PH2.7 (10g/l, H2O, 20℃)
OdorOdorless
Water Solubility Soluble in water, glycerin, glycol and ethanol.
Sensitive Hygroscopic
λmax532 nm
Decomposition 290 °C
Merck 14,3941
BRN 5718212
Stability:Stable. Incompatible with strong oxidizing agents.
Biological ApplicationsDrug delivery and tissue engineering; photodynamic therapy; dental materials; treating cancer,diabetes; wound dressing materials
LogP-5.42 at 25℃
IARC3 (Vol. 16, Sup 7) 1987
EPA Substance Registry SystemC.I. Food Green 3, disodium salt (2353-45-9)
Safety Information
Hazard Codes Xn
Risk Statements 68-40-20/21/22
Safety Statements 22-24/25-37/39-25-36/37
WGK Germany 3
RTECS BQ4425000
3
TSCA Yes
HS Code 32041900
Hazardous Substances Data2353-45-9(Hazardous Substances Data)
ToxicityLD50 orally in rats: >2 g/kg (Lu, Lavalle)
Fast Green FCF Usage And Synthesis
DescriptionFD & C Green No. 3 is principally the inner salt disodium salt of N-ethyl-N-[4-[[4-[ethyl[(3-sulfophenyl)methyl] amino]phe- nyl](4-hydroxy-2-sulfophenyl)methylene]-2,5-cyclohexadien- 1 -ylidene]-3-sulfobenzenemethanaminium hydroxide.
The colorant is a red to brown-violet powder or collection of crystals that dissolves in water to give a solution blue-green at neutrality, green in acid, and blue-violet in base. When dissolved in concentrated sulfuric acid, it yields a brown-orange solution that turns green when diluted with water. When heated to 130° with glycerine triacetate and an excess of acetic anhydride, acety- lation of its phenolic hydroxyl group causes a color change from green to light blue.
Fast Green FCF is regularly used in beverages, desserts (puddings, ice cream, sherbet), candy, bakery goods, dairy products, and maraschino cherries. The color is also used in pharmaceuticals, cosmetics and histological stains.1 .

Chemical Propertiesgreen powder
UsesBiological stain. Color additive in food, drugs and cosmetics.
UsesFast Green FCF is a colorant. It has good ph stability, showing after 1 week a slight fade at ph 3, a very slight fade at ph 5 to 7, and slight fade and appreciably bluer color at ph 8. It has excellent solubility in water with a solubility of 20 g in 100 ml at 25°c. It has fair to good stability to light, poor stability to oxidation, and shows no appreciable change in 10% sugar systems. It has a bluish-green hue, with excellent tinctorial strength. It has good compatibility with food components and is occasionally used in cereals, soft drinks, beverages, and desserts.
UsesStain for showing collagen, muscle, cytoplasm and cells in mammalian tissuesFast Green FCF is used as a quantitative stain for histones and protein stain in electrophoresis. It is also used as a food dye, which is poorly absorbed by intestine. It is used for tinned green peas and other vegetables, jellies, sauces, fish and desserts. It is considered as a replacement of Light Green SF yellowish in Masson's trichrome. Further, it is utilized in tissue stain.
DefinitionChEBI: An organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellow sh in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent.
General DescriptionFast Green FCF is one of the triarylmethane dyes, that is biocompatible. This triphenylmethane color additive is mainly used in coloring food, drugs and cosmetics.
Flammability and ExplosibilityNonflammable
Biochem/physiol ActionsFast Green FCF can be considered as a safe stain to detect tumor. In recent years, this has gained importance as an important drug to treat amyloid-deposit diseases.
Properties and Applicationsblue light green. Soluble in water for blue light green, soluble in ethanol for blue light green. The strong sulfuric acid for dark orange, diluted dark for; In strong hydrochloric acid or nitric acid are all the orange solution; In 10% of sodium hydroxide solution for light blue.
Methyl RHODAMINE B ISOTHIOCYANATE PRIMOCYANINE 6GX GREEN TEA Basic Blue 26 VICTORIA BLUE 4R CI NO 42585 Basic Blue 7 Kresoxim-methyl PHENYL VALERATE NIGHT BLUE ETHYL VIOLET Thiophanate-methyl METHYL GREEN PYRONINE RHODAMINE B AMINE CRYSTAL VIOLET RHOD 2 TRIAMMONIUM SALT CHLOROPHOSPHONAZO III

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