ChemicalBook Product Catalog Biochemical Engineering Inhibitors Nuclear transcription factor (NF-κB) IκB / IKK inhibitors IKK 16

IKK 16

IKK 16 Basic information
Product Name:IKK 16
Synonyms:IKK Inhibitor;[4-[(4-Benzo[b]thien-2-yl-2-pyriMidinyl)aMino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-Methanone;IKK Inhibitor VII;Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-;1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine IKK-16 (IKK Inhibitor VII);1-[4-[(4-Benzo[b]thien-2-yl-2-pyrimidinyl)amino]benzoyl]-4-(1-pyrrolidinyl)piperidine;IKK16;IKK-16;IKK INHIBITOR VII;CS-1847
CAS:873225-46-8
MF:C28H29N5OS
MW:483.63
EINECS:
Product Categories:NF-kB;IκB/IKK;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds;Inhibitors
Mol File:873225-46-8.mol
IKK 16 Structure
IKK 16 Chemical Properties
storage temp. Store at -20°C
solubility ≥23.05 mg/mL in DMSO; ≥11.3 mg/mL in EtOH with ultrasonic; insoluble in H2O
form solid
Safety Information
MSDS Information
IKK 16 Usage And Synthesis
UsesIKK-16 is a potential novel IκB kinase 2 (IKK2) inhibitor used in the treatment of various immune/inflammatory disorders.
DefinitionChEBI: [4-[[4-(1-benzothiophen-2-yl)-2-pyrimidinyl]amino]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.
Biological Activityikk-16 (ikk inhibitor vii) is a novel inhibitor of iκb kinase (ikk) with the ic50 values of 0.04μm, 0.2μm and 0.07μm for ikk2, ikk1 and ikk complex, respectively [1].ikk-16 (ikk inhibitor vii) is a 2-benzamido-pyrimidines and selective inhibitor of iκb kinase (ikk). ikk-16 has been reported to effectively inhibit tnfα release into plasma upon lps-challenge in the rat. in addition, ikk-16 has been found to be active at thioglycollate-induced peritonitis model in the mouse. furthermore, ikk-16 has revealed to be an orally bio-available in rats and mice, and have significant in vivo activity in an acute model of cytokine release [1].
targetIKK-2
references[1] waelchli r1, bollbuck b, bruns c, buhl t, eder j, feifel r, hersperger r, janser p, revesz l, zerwes hg, schlapbach a.design and preparation of 2-benzamido-pyrimidines as inhibitors of ikk. bioorg med chem lett. 2006 jan 1;16(1):108-12. epub 2005 oct 19.
IKK 16 Preparation Products And Raw materials
IKK Inhibitor III, BMS-345541 Trametinib NA TPCA-1 MK-2206 2HCl QNZ (EVP4593) INK 128 (MLN0128)
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