DIETHYLPROPION

DIETHYLPROPION Basic information
Product Name:DIETHYLPROPION
Synonyms:1-Phenyl-2-diethylamino-1-propanone;2-(diethylamino)-1-phenyl-1-propanon;2-(Diethylamino)-1-phenyl-1-propanone;2-(diethylamino)-propiophenon;2-(diethylamino)propiophenone;2-(Diethylaminopropio)phenone;2-diethylamino-propiophenon;2-diethylaminopropiophenone
CAS:90-84-6
MF:C13H19NO
MW:205.3
EINECS:202-019-1
Product Categories:
Mol File:90-84-6.mol
DIETHYLPROPION Structure
DIETHYLPROPION Chemical Properties
Boiling point 292℃
density 0.972
refractive index 1.5175 (estimate)
Fp 95℃
pka8.49±0.25(Predicted)
EPA Substance Registry SystemDiethylpropion (90-84-6)
Safety Information
Hazardous Substances Data90-84-6(Hazardous Substances Data)
MSDS Information
DIETHYLPROPION Usage And Synthesis
OriginatorTenuate,Merrell National ,US,1959
Usesappetite depressant;stimulating secretion of norepinephrine
DefinitionChEBI: An aromatic ketone that is propiophenone in which one of the hydrogens alpha- to the carbonyl is substituted by a diethylamino group. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as the hydrochloride as an anoretic in the short term management of obesity.
Manufacturing Process1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.
Brand nameAdiposan;Adipyn;Alipid;Amfepromone;Apisate;Bonumin;Brenalalit;Brendalit;Controlgras;D.i.p.n;Delgamer;Deramix;Dietec;Dietil retard;Dietil-retard;Lineal-plus;Lineal-rivo;Lineal-valeas;Linea-valeas;Lipomin;Liposlim;Menutil;Moderatan diffucap;Nobensin-75;Nobensine;Nobesine-25;Nulobes;Perfamone;Prefamone;Redicres;Regenon retard;Regibon;Sinapet;Slim-plus;Super emegrin;T-712;Tenuate dospan;Tenucap.
Therapeutic FunctionAnorexic
World Health Organization (WHO)Amfepramone, a phenethylamine derivative introduced in 1957, is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. It remains available in many other countries with highly evolved drug regulatory authorities as an aid to weight reduction.(Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)
DIETHYLPROPION Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Diethylamine
(+/-)-Ethylketazocine 1-Propanone, 2-diethylamino-1-(2-naphthalenyl)-, hydrochloride 3,6-BIS(2-METHYL-2-MORPHOLINOPROPIONYL)-9-OCTYLCARBAZOLE AURORA KA-2293 CHEMBRDG-BB 5406291 AURORA KA-3562 Ketazocine AURORA KA-2301 AURORA KA-2295 DIETHYLPROPION HYDROCHLORIDE,DIETHYLPROPION HYDROCHLORIDE SYMPATHOMIM ETIC, ANOR,AMFEPRAMONE HYDROCHLORIDE (DIETHYLPROPION HYDROCHLORIDE) ETHYLKETOCYCLAZOCINE, (-)-[9-3H]- alpha-Phthalimidopropiophenone 1-(4-Acetylaminophenyl)-2-(4-methylpiperazino)propanone dihydrochlorid e Ketazocine hydrochloride 4'-methyl-2-(1-pyrrolidinyl)valerophenone hydrochloride 2-BENZOXAZOLINONE, 6-(2-(4-(p-FLUOROPHENYL)-1-PIPERAZINYL)PROPIONYL)-3 -METHYL- DIETHYLPROPION 2-Methyl-4'-(methylthio)-2-morpholinopropiophenone

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