Carbazochrome

Carbazochrome Basic information
Product Name:Carbazochrome
Synonyms:CROMADRENAL;CROMOSIL;CARBAZOCHROME;3-HYDROXY-1-METHYL-5,6-INDOLINEDION 5-SEMICARBAZONE;3-hydroxy-1-methyl-5,6-indolinedione 5-semicarbazone;3-HYDROXY-1-METHYL-5,6-INDOLINEDIONE SEMICARBAZONE;ADENOCHROME SEMICARBAZONE;ADRENOXYL
CAS:69-81-8
MF:C10H12N4O3
MW:236.23
EINECS:200-717-0
Product Categories:69-81-8
Mol File:69-81-8.mol
Carbazochrome Structure
Carbazochrome Chemical Properties
Melting point 203° (dec)
density 1.63±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Water (Slightly, Heated)
form Solid
pka12.38±0.40(Predicted)
color Dark Orange to Very Dark Orange
Water Solubility Water: 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH)
Merck 14,172
Stability:Hygroscopic
CAS DataBase Reference69-81-8(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS NM1925500
HS Code 29339900
MSDS Information
Carbazochrome Usage And Synthesis
OriginatorAdrenosem,Beecham,US,1953
UsesCarbazochrome is an oxidation product of Epinephrine [E588580]) that improves microcirculatory tone. Derivatives such as carbazochrome salicylate and carbazochrome sodium sulfonate, are used as hemostats and treatment to prevent dengue shock syndrome, respectively.
DefinitionChEBI: Carbazochrome is a member of indoles. It is functionally related to a semicarbazide.
Manufacturing ProcessA suspension containing 1 part by weight of adrenalin and 2 to 6 parts by weight of silver oxide in 150 to 250 parts by weight of methanol or ethanol is stirred for about 10 minutes. The alcoholic adrenochrome solution obtained is separated by draining and the filtrate is quickly evaporated to dryness at low temperature and in vacuo. The red crystals of adrenochrome obtained are dissolved in 45 to 55 parts by weight of water. To this solution, 2 parts of sodium acetate dissolved in 2 to 3 parts of water and 2 parts of semicarbazide hydrochloride dissolved in 2 to 3 parts of water are added. The formed precipitate consisting of red-orange prismatic needles is separated by filtration and recrystallized from diluted ethanol. There is obtained 0.30 to 0.40 part by weight of adrenochrome monosemicarbazone dihydrate, melting at 203°C with decomposition.
Therapeutic FunctionHemostatic
Carbazochrome Preparation Products And Raw materials
Raw materialspotassium ferricyanide-->Adrenalone hydrochloride-->L(-)-Epinephrine-->Semicarbazide hydrochloride-->Silver oxide
Methylparaben Corticotropin Nitrofurazone Methyl CARBAZOCHROME SALICYLATE,CARBAZOCHROME SODIUM,CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE 1,1,3,3-Tetramethylurea Basic Violet 1 Tribenuron methyl 1,3-Bis(trimethylsilyl)urea Kresoxim-methyl CORTISONE Methanol Biuret Methyl salicylate Methyl acrylate CHLOROPHOSPHONAZO III Carbazochrome METSULFURON METHYL

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