Adenosine 5'-monophosphate

Adenosine 5'-monophosphate Basic information
Chemical Properties Applications Preparation Usage restriction Category Toxicity Grading Acute Toxicity Flammability Hazardous Characteristics Storage and Transport Extinguishing Agent
Product Name:Adenosine 5'-monophosphate
Synonyms:a5mp;adenosine,mono(dihydrogenphosphate)(ester);Adenosine -5'- Monophosphate(AMP-H);)-monophosphate disodium salt (mixed isomers);4-PREGNEN-18-OL, 3, 20-DIONE (20α;OLS) 18, 20-HEMIKETAL;3-Hydroxy Tibolone-d5 |(mixture of 3α;adenosine5’-phosphate
CAS:61-19-8
MF:C10H14N5O7P
MW:347.22
EINECS:200-500-0
Product Categories:Nucleic acids;Pharmaceutical Intermediates;Organic acids;Heterocyclic Compounds;Biochemistry;Nucleosides, Nucleotides & Related Reagents;Nucleotides and their analogs;ZADITOR;BEAUTY PEPTIDES;Inhibitors;Pharmaceutical;61-19-8
Mol File:61-19-8.mol
Adenosine 5'-monophosphate Structure
Adenosine 5'-monophosphate Chemical Properties
Melting point 178-185 °C
Boiling point 798.5±70.0 °C(Predicted)
density 2.32±0.1 g/cm3(Predicted)
FEMA 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: with addition of mild alkalisoluble
form Crystalline Powder
pka3.8, 6.2(at 25℃)
color Colorless to white
Water Solubility Soluble in water.
Merck 14,158
Stability:Hygroscopic
InChIInChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyUDMBCSSLTHHNCD-KQYNXXCUSA-N
SMILESP(OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O)(O)(O)=O
CAS DataBase Reference61-19-8(CAS DataBase Reference)
EPA Substance Registry System5'-Adenylic acid (61-19-8)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS AU7480500
TSCA Yes
HS Code 29389090
Hazardous Substances Data61-19-8(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in mouse: 4gm/kg
MSDS Information
ProviderLanguage
5'-Adenylic acid English
SigmaAldrich English
ACROS English
Adenosine 5'-monophosphate Usage And Synthesis
Chemical PropertiesWhite crystalline powder. Melting point: 196-200°C (decomposition). Specific optical rotation:-47.5° (20°C, 2% in sodium hydroxide (2%)). Soluble in water, slightly soluble in alcohol, insoluble in ether.
ApplicationsClinically it is used to treat disseminated sclerosis, porphyria, itching, liver disease, varicose ulcer complication. Eye drops with denosine monophosphate as the main component can be used to treat eye fatigue, central amphiblestitis, ocular pannus,  herpes and other corneal surface diseases. Intramuscular injection shows local erythema, generalized essential telangiectasia, red face, dizziness, breathing difficulty and palpitation.
As nutrition enhancer; as intermediate to produce nucleotide drugs; as food additive; as biological products; as dietary supplement and biochemical reagent. It is used to produce adenosine triphosphate (ATP), cyclic adenylate (cAMP) and other biochemical drugs. It is a type of nucleotide products and to produce antiviral drugs, synthetic energy drugs and cardiovascular and cerebrovascular drugs, such as adenosine, ATP, 3 '-5'-cyclic adenosine monophosphate.
PreparationCandida utilis fungi is treated with hot water to obtain nucleic acids, which is hydrolyzed by enzymes and separated to obtain the final product.
Take mycelia as the raw material:
Subtraction and sedimentation of mycelia are carried out with 3 times amount of water. Industry base is added to reach a base concentration of 0.25% (g/100mL). After stirring for 1 hours, 20% sulfuric acid is added until the PH value is 7. The solution is filtrated and the pH value of filtrate is adjusted with 20% sulfuric acid to 2.5. Centrifugation is then applied to obtain nucleic acid mud.
mycelia [sodium hydroxide]→[1h] extract solution [20% sulfuric acid] → [pH=7, filtration] filtrate [20% sulfuric acid] →[pH=2.5, centrifugation] nucleic acid mud
1% nucleic acid solution is made by subsequent dissolution, enzymolysis, absorption and elution. 10% ammonia water is then used to adjust the pH value to 6-6.2. Then the mixture is heated at 90°C for 20 min and cooled. After centrifugation, the supernatant is heated up to 65-70°C and added with 1/3 phosphodiesterase solution. After 2 hours, the temperature is raised to 90°C.  10min later, it is cooled to room temperature. 20% sulfuric acid is added to adjust the pH value to 2.5-3. After filtration, the filtrate is adjusted with ammonia solution until the pH=7.2-7.5. 0.3% (3 g/L) diatomite is then added to assist the filtration. The corresponding supernatant is filtered with an anion exchange resin column (717-type) and eluted with 0.05 mol/L sulfuric acid. Afterwards, absorption, elution and crystallization are carried out. The detailed procedures of these three steps are:
The eluate is first absorbed with a cation exchange column (732-type) and eluted with distilled water (pH=1.5). The collection of eluate starts when the eluate turned red with bromine water. The eluate is then concentrated to 80-90 mg/mL under reduced pressure, added with diatomite and stirred for 30 min before filtration. The filtrate is adjusted with 6 mol/L hydrochloric acid till pH=2.5. To realize full crystallization, the filtrate is cooled during stirring. After followed filtration, it is washed with dry ethanol for 3 times. Vacuum drying at 60°C is applied to obtain the final AMP products.
Nucleic acid mud [ammonia gas] →[pH=6-6.2, 90°C, 20min] supernatant [phosphodiesterase] →[65-70°C,2h,] hydrolysis solution [717 resin] →absorbent [sulfuric acid] →elution solution [732 resin] →AMP, CMP, GMP absorbent mixtures.





Usage restrictionGB 2760-2001:infant formula milk powder 0.2~0.58 g/kg (based on the total amount of nucleotide)
CategoryToxic substance
Toxicity GradingMiddle toxicity
Acute ToxicityPeritoneal-mouse LD50: 4000 mg/kg
Flammability Hazardous CharacteristicsFlammable; generation of toxic nitrogen oxides and phosphorous oxide smoke when heated.
Storage and TransportStored in well ventilated area, low temperature, and dry.
Extinguishing AgentDry powder, foam, sand, carbon dioxide.
DescriptionAdenosine-5'-monophosphoric acid is a nucleotide that is synthesized from adenosine triphosphate and inosine monophosphate. Adenosine-5'-monophosphoric acid is an important molecule in the body because it is a substrate for cyclic AMP, which regulates many cellular processes. Adenosine-5'-monophosphoric acid also has biochemical properties that are similar to those of the neurotransmitter serotonin and it can activate the 5-HT2 receptors.
Chemical Propertiescolorless to white crystalline powder
Usesantiasthmatic
Usesvasodilator, neuromodulator
UsesAdenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists.
UsesA useful ligand determinant that facilitates the binding of APS reductase inhibitors.
UsesAdenosine 5'-monophosphate is a nucleotide (building blocks of nucleic acid) added to skin care products to bind water and moisture.
DefinitionChEBI: A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase.
Brand nameAdenyl (Wyeth-Ayerst); My-BDen (Bayer.
Biological Activityadenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
Safety ProfileSlightly toxic by intraperitoneal route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of PO, and NOx.
Adenine Adenosine 2-Amino-2-methyl-1-propanol Adenine phosphate salt(1:1) Adenine hydrochloride Ethyl 2-(Chlorosulfonyl)acetate Adenine phosphate(1:x) Ascoric Acid Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) Folic acid ADENOSINE 5'-TRIPHOSPHATASE PUROMYCIN AMINONUCLEOSIDE ADP 5'-Guanylic acid tevenel 6-Chloropurine ribonucleoside Adenosine cyclic monophosphate Adenine hydrochloride hemihydrate

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