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| Melting point | 45-45.5 °C | | Boiling point | 124.5-126.5 °C(Press: 0.5 Torr) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at +4°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Off-white powder. | | pka | 2.97±0.12(Predicted) | | color | White to Off-White | | Stability: | Light Sensitive |
| Uses | A potent, subtype selective mGluR5 antagonist | | Uses | 2-Methyl-6-(2-phenylethynyl)pyridine induces pathophysiological mGluR5 signaling in Alzheimer''s disease model mice in sex-selective manner. | | Uses | MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3). | | Definition | ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene. | | Biological Activity | Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ . | | references | [1] gasparini f, lingenhöhl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, kłodzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430. |
| | MPEP Preparation Products And Raw materials |
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