Salinomycin

Salinomycin Basic information
Product Name:Salinomycin
Synonyms:coxistac;SALINOMYCIN GRANULE;Salinomycin Premix 12%;SALINOMYCIN FROM STREPTOMYCES ALBUS;SALINOMYCIN 90%;SV sodium salt,2,5 salinomycin hydrate;(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid;Salinomycin
CAS:53003-10-4
MF:C42H70O11
MW:751
EINECS:258-290-1
Product Categories:KOKCISAN;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;Chemical Structure Class;L - ZAntibiotics;Mechanism of Action;Monovalent Ion Channels;Polyethers;Inhibitors;Interferes with Cell Membrane Permeability (Ionophores)Voltage-gated Ion Channels;IonophoresSpectrum of Activity;53003-10-4
Mol File:53003-10-4.mol
Salinomycin Structure
Salinomycin Chemical Properties
Melting point 112.5-113.5 °C(lit.)
Boiling point 839.2±65.0 °C(Predicted)
alpha D25 -63° (c = 1 in ethanol)
density 1.18±0.1 g/cm3(Predicted)
Fp >110°(230°F)
storage temp. Sealed in dry,2-8°C
solubility insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO
pka6.4 (DMF)
form White solid
Water Solubility Soluble in methanol. Insoluble in water
Merck 13,8415
Stability:Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
LogP5.596 (est)
CAS DataBase Reference53003-10-4(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 25-36/37/38
Safety Statements 45-36-26
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS VO8620000
10
HazardClass 6.1(a)
PackingGroup II
Hazardous Substances Data53003-10-4(Hazardous Substances Data)
ToxicityLD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)
Salinomycin Usage And Synthesis
Chemical Propertiessolid
UsesSalinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.
Usesantibacterial
UsesSalinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.
DefinitionChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore.
General DescriptionChemical structure: polyether
Biological Activitysalinomycin (sal), which is a polyether ionophore antibiotic from streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with abc drug transporters, the wnt/β-catenin signaling pathway, or other pathways.
Biochem/physiol ActionsSalinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.
in vitroseveral hepatocellular carcinoma (hcc) cell lines were treated with sal. results showed that sal inhibited proliferation and decreased pcna levels. cell cycle analysis showed that sal caused cell cycle arrest in different phases. sal induced apoptosis as characterized by an increase in the bax/bcl-2 ratio. compared to control, β-catenin expression was down-regulated by sal treatment significantly. the ca2+ concentration in hcc cells was examined by flow cytometry and it was found that higher ca2+ concentrations were observed in sal treatment groups [1].
in vivothe in vivo anti-tumor effect of sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in sal-treated groups decreased. immunohistochemistry and tunel staining also demonstrated that sal could in vivo inhibit proliferation and induced apoptosis [1].
IC 507.7, 13.7 and 10.4 μm for hepg2, smmc-7721 and bel-7402 cell line, respectively (after 24h treatment)
references[1] wang f,he l,dai wq,xu yp,wu d,lin cl,wu sm,cheng p,zhang y,shen m,wang cf,lu j,zhou yq,xu xf,xu l,guo cy. salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo. plos one.2012;7(12):e50638.
Salinomycin Preparation Products And Raw materials
Bengenin SODIUM SALINOMYCIN Salinomycin benzyl ester DIPENTOXYETHANE 2,4-DIMETHYL-3-HEXANONE Salinomycin, 4-methyl-, (4S)- Granulose SALINOMYCIN PREMIX 3-HYDROXYOCTANOIC ACID SODIUM ISOBUTYRATE (S)-1-OCTEN-3-OL 3-methoxybutyric acid CIS-2-METHYL-7-OCTADECENE 4-METHYL-1-PENTEN-3-OL 1,2,9-NONANETRIOL CHLOROPHOSPHONAZO III Granulose salinomyclin Salinomycin sodium (850u/mg up)

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