Trimethyl orthobenzoate

Trimethyl orthobenzoate Basic information

Product Name:	Trimethyl orthobenzoate
Synonyms:	(trimethoxymethyl)-benzen;Orthobenzoic acid, trimethyl ester;à,à,à-trimethoxytoluene;Thrimethyl orthobenzoate;Phenylorthoformic acid trimethyl ester;Phenyltrimethoxymethane;Trimethoxyphenylmethane;Trimethyl orthobenzoate,97%
CAS:	707-07-3
MF:	C10H14O3
MW:	182.22
EINECS:	211-897-5
Product Categories:	Acetals/Ketals/Ortho Esters;Organic Building Blocks;Oxygen Compounds;bc0001;707-07-3
Mol File:	707-07-3.mol

Trimethyl orthobenzoate Chemical Properties

Boiling point	87-88 °C/7 mmHg (lit.)
density	1.061 g/mL at 25 °C (lit.)
refractive index	n20/D 1.489(lit.)
Fp	180 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in organic solvents.
form	Liquid
color	Clear colorless
Sensitive	Moisture Sensitive
BRN	777623
Stability:	Hygroscopic
InChIKey	IECKAVQTURBPON-UHFFFAOYSA-N
CAS DataBase Reference	707-07-3(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, (trimethoxymethyl)-(707-07-3)
EPA Substance Registry System	Benzene, (trimethoxymethyl)- (707-07-3)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39-37/39
WGK Germany	3
TSCA	Yes
HS Code	29163100

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Trimethyl orthobenzoate Usage And Synthesis

Chemical Properties	clear colorless liquid
Uses	Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.
Synthesis Reference(s)	Journal of the American Chemical Society, 72, p. 1661, 1950 DOI: 10.1021/ja01160a067
General Description	Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.

Trimethyl orthobenzoate Preparation Products And Raw materials

Raw materials	Tetramethoxymethane-->Benzenecarboximidic acid methyl ester-->N-methylbenzanilide
Preparation Products	Benzamide-->(E)-Methyl 1-acetyl-3-(Methoxy(phenyl)Methylene)-2-oxoindoline-6-carboxylate-->2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester-->tert-Butyl 4-oxo-2-phenyl-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate

2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-(2-methyl-2-pr openyl)- 2,6,7-Trioxabicyclo(2.2.2)octane, 4-(2,2-dimethylpropyl)-1-(4-ethynylp henyl)- MEZEREIN ((4-(4-Propyl-2,6,7-trioxabicyclo(2.2.2)oct-1-yl)phenyl)ethynyl)trimet hylsilane ((4-(4-Butyl-2,6,7-trioxabicyclo(2.2.2)oct-1-yl)phenyl)ethynyl)trimeth ylsilane 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-(2-methylcyclo propyl)-, trans- 2,6,7-Trioxabicyclo(2.2.2)octane, 4-butyl-1-(4-ethynylphenyl)- 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-(4-fluoropheny l)- THYMELEATOXIN 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-(3-fluoropheny l)- 2,6,7-Trioxabicyclo(2.2.2)octane, 4-cyclopropyl-1-(4-ethynylphenyl)- [3H]TBOB 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-(2-fluoropheny l)- 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-ethynylphenyl)-4-pentyl- EBOB, [PROPYL-2,3-3H]- 2,6,7-Trioxabicyclo(2.2.2)octane, 1-(4-(3,3-dimethyl-1-butynyl)phenyl) -4-propyl- ((4-(4-Pentyl-2,6,7-trioxabicyclo(2.2.2)oct-1-yl)phenyl)ethynyl)trimet hylsilane 2,6,7-Trioxabicyclo(2.2.2)octane, 4-t-butyl-1-phenyl-

Email:[email protected] [email protected]

Copyright © 2024 Mywellwork.com All rights reserved.