ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Chloropyrimidine 4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine

4-Chloro-2-methylthiopyrimidine Basic information
Product Name:4-Chloro-2-methylthiopyrimidine
Synonyms:4-Chloro-2-(methylmercapto)pyrimidine;4-Chloro-2-(methylsulphanyl)pyrimidine 97%;4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE;4-Chloro-2-(methylthio)pyrimidine 97%;2-methylthio-4-chloropyrimine;2-(Methylthio)-4-chloropyrimidine;4-Chloro-2-(methylthio)pyrimidine ,98%;4-Chloro-2-(Methylthio)py...
CAS:49844-90-8
MF:C5H5ClN2S
MW:160.62
EINECS:256-500-6
Product Categories:Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Halides;Pyrazines, Pyrimidines & Pyridazines;Pyrimidine;Heterocycle-Pyrimidine series
Mol File:49844-90-8.mol
4-Chloro-2-methylthiopyrimidine Structure
4-Chloro-2-methylthiopyrimidine Chemical Properties
Melting point −2 °C(lit.)
Boiling point 139-140 °C36 mm Hg(lit.)
density 1.381 g/mL at 25 °C(lit.)
refractive index n20/D 1.6(lit.)
Fp >230 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form liquid
pka-0.56±0.20(Predicted)
color Colorless to Red to Green
Water Solubility Not miscible or difficult to mix in water.
Sensitive Hygroscopic
BRN 118042
InChIKeyDFOHHQRGDOQMKG-UHFFFAOYSA-N
CAS DataBase Reference49844-90-8(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-36/37/39-45
RIDADR UN 1760 8/PG 2
WGK Germany 3
F 10-13-23
Hazard Note Corrosive/Hygroscopic
HazardClass 8
PackingGroup III
HS Code 29335990
MSDS Information
ProviderLanguage
4-Chloro-2-methylthiopyrimidine English
SigmaAldrich English
ALFA English
4-Chloro-2-methylthiopyrimidine Usage And Synthesis
Chemical PropertiesClear yellow to brown liquid
UsesIt finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
Uses4-Chloro-2-methylthiopyrimidine was used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It was used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors. It was used as building block in medicinal chemistry synthesis.
5-CARBETHOXY-4-CHLORO-2-ETHYL-MERCAPTOPYRIMIDINE Sulfamerazine MCPA SOLUTION 100 NG/MYL IN ACETONITRIL& 5-Bromo-4-chloro-2-(methylthio)pyrimidine ,97%,5-Bromo-4-chloro-2-(methylthio)pyrimidine 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester,Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate 98% Chloromethyl methyl ether tert-Butyldimethylsilyl chloride 4-CHLORO-7-CYCLOHEXYL-6,7-DIHYDRO-2-(METHYLTHIO)-(5H)-PYRROLO[2,3-D]PYRIMIDINE 4,6-DICHLORO-2-METHYLTHIO-PYRIMIDINE, [4,6-14C] Difluorochloromethane 4-AMINO-6-CHLORO-2-(METHYLTHIO)PYRIMIDINE ISOMETHIOZIN Pyrimidine Phenyl chlorothionocarbonate 4-Chloro-6-methyl-2-(methylthio)pyrimidine 4-Chloro-2-methylthiopyrimidine 4,6-DICHLORO-2-METHYLTHIO-5-PHENYLPYRIMIDINE WY-14643
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