Iron-dextran

Iron-dextran Basic information
Product Name:Iron-dextran
Synonyms:fe-dextran;fenate;ferdex100;ferricdextran;ferridextran;ferrodextran;ferroglucin;ferroglukin75
CAS:9004-66-4
MF:FeH2O4S
MW:153.92348
EINECS:202-785-7
Product Categories:API;API's;9004-66-4
Mol File:9004-66-4.mol
Iron-dextran Structure
Iron-dextran Chemical Properties
storage temp. Room Temperature
solubility Water (Slightly)
form solution
color Very Dark Red to Black
Water Solubility Iron, ~100?mg/mL in water
IARC2B (Vol. 2, Sup 7) 1987
EPA Substance Registry SystemIron dextran (9004-66-4)
Safety Information
Hazard Codes Xn,T
Risk Statements 40-42/43-43-45
Safety Statements 23-26-36/37/39-45-36-36/37-53
WGK Germany -
RTECS NI2200000
Hazardous Substances Data9004-66-4(Hazardous Substances Data)
ToxicityLD50 i.v. in mice: 2240 mg Fe/kg (Beliles)
MSDS Information
ProviderLanguage
Ferric hydroxide dextran complex English
SigmaAldrich English
Iron-dextran Usage And Synthesis
DescriptionIron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292)
Iron-Dextran is for the parenteral treatment of iron-deficiency anemia in humans and baby pigs. Can be used as a reagent.
Chemical PropertiesLight to dark brown powder. Colloidal suspension of an iron-dextran complex in water. pH 5.2-6.5.
HistoryThe therapeutic value of colloidal iron preparations was first reported in the 1950's by London and Twigg. Numerous attempts have been made to improve these iron preparations Thus dextran ([h] 0.05) is first heated with alkali, and is then neutralized in the presence of ferric chloride solution. Studies on this product have revealed that each particle consists of a central iron core, approximately 3nm diameter, surrounded by a dextran sheath of approximately 13nm diameter. The complex is visualized as a particle formed by a protective sheath of dextran attached by terminal metasaccharinic acid units to a b-FeOOH core. A solution of this complex containing 5% iron and 20% dextran (Imferon ™ ) is suitable for intramuscular and intravenous injection for treating iron deficiency anemia. The product is currently used widely for treating anemia in new-born piglets.
The use of these preparations has been re-examined in humans and a dramatic rise in hemoglobin was reported following intravenous infusion. The solution is best administered together with glucose solutions.
UsesHematinic.
UsesIron-Dextran (ferric hydroxide dextran complex) may be used as an intravenous iron delivery preparation. Iron-Dextran may be used to induce iron-overload to study its effects and preventative measures.
Brand nameDexferrum (Luitpold); Infed (Wat son); Proferdex (New River).
Reactivity ProfileIron-dextran is unstable at a pH of 5 and decomposes at 149-158° F. Iron-dextran may be sensitive to prolonged exposure to air.
Health HazardSYMPTOMS: The symptoms associated with exposure to Iron-dextran are headaches, vomiting, and dizziness.
Fire HazardIron-dextran is combustible.
Clinical UseProphylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated)

Treatment of iron deficiency during ESA therapy especially if serum ferritin is very low (<50 nanograms/mL)

Drug interactionsPotentially hazardous interactions with other drugs
Dimercaprol: avoid concomitant use.
Oral iron: reduced absorption of oral iron

CarcinogenicityIron dextran complex is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
MetabolismAfter intravenous infusion, iron dextran is taken up by the cells of the reticuloendothelial cells, particularly in the liver and spleen. The reticuloendothelial cells gradually separate iron from the iron-dextran complex. Most absorbed iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin; the remainder is contained within the storage forms, ferritin or haemosiderin, or as myoglobin, with smaller amounts occurring in haem-containing enzymes or in plasma bound to transferrin.
Only very small amounts of iron are excreted as the majority released after the destruction of the haemoglobin molecule is re-used.
Iron-dextran Preparation Products And Raw materials
Preparation ProductsDextran
iron dextran complex injection. METHYL ISOCYANOACETATE N-BUTYLISOCYANIDE Ammonium hydroxide PHENYLSELENOL SEPHADEX G-10 BLUE DEXTRAN SEPHADEX G-50 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide Ethyl isocyanoacetate Sodium hydroxide TERT-BUTYL ISOCYANIDE Ferric phosphate Benzyl isocyanide Iron-dextran Dextran Sulfate Sodium Salt Ammonium ferric citrate

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