Levocetirizine dihydrochloride

Levocetirizine dihydrochloride Basic information
Product Name:Levocetirizine dihydrochloride
Synonyms:LEVOCETIRIZINE 2HCL;LEVOCETIRIZINE DIHCL;LEVOCETIRIZINE DIHYDROCHLORIDE;LEVOCETIRIZINE HCL;LEVOCETRIZINE DIHYDROCHLORIDE;[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;[2-[4-[(R)-(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINYL]ETHOXY]-ACETIC ACID 2HCL;(R)-Cetirizine (hydrochloride)
CAS:130018-87-0
MF:C21H27Cl3N2O3
MW:461.81
EINECS:641-093-3
Product Categories:Antibiotics;Levocitirizine 2HCl;API's;Levocetirizine;Histamine receptor;API
Mol File:130018-87-0.mol
Levocetirizine dihydrochloride Structure
Levocetirizine dihydrochloride Chemical Properties
Melting point 215-220°C
alpha D25 -12.79° (c = 1 in water)
storage temp. room temp
solubility H2O: ≥23mg/mL
form powder
color White to Almost white
Merck 14,2022
Stability:Hygroscopic
CAS DataBase Reference130018-87-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS AG0990000
HS Code 29335990
MSDS Information
Levocetirizine dihydrochloride Usage And Synthesis
UsesAnti Histaminic
UsesLevocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.
General DescriptionLevocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine .
Biochem/physiol ActionsLevocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.
Levocetirizine dihydrochloride Preparation Products And Raw materials
Promethazine hydrochloride Ethyl 2-(Chlorosulfonyl)acetate Acetic anhydride Ascoric Acid 4-Ethoxyphenol Cetirizine DIETHOXYMETHANE Chlorophenyl Ethoxyquin Levocetirizine Piperazine Cetirizine hydrochloride Ethoxy Dihydrochloride Levoceitrizine Hcl Levocetirizine dihydrochloride Phenylacetic acid 2-Ethoxyphenol

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