Diethyl ethylmalonate

Diethyl ethylmalonate Basic information

Product Name:	Diethyl ethylmalonate
Synonyms:	Diethyl 2-ethylmalonate;Ethylethylmalonate;Ethylmalonicacid,diethylest;DIETHYL ETHYLMALONATE FOR SYNTHESIS;Ethyl Malonic acidethyl ester two;Diethyl EthylMalonate, 98.0%(GC);Diethyl ethylMalonate, 99% 100GR;1,3-Diethyl 2-ethylpropanedioate
CAS:	133-13-1
MF:	C9H16O4
MW:	188.22
EINECS:	205-093-3
Product Categories:	C8 to C9;Carbonyl Compounds;Pharmaceutical Intermediates;TheMalonateRamificationProducts;Esters;bc0001
Mol File:	133-13-1.mol

Diethyl ethylmalonate Chemical Properties

Melting point	0°C
Boiling point	75-77 °C/5 mmHg (lit.)
density	1.004 g/mL at 25 °C (lit.)
refractive index	n20/D 1.416(lit.)
Fp	191 °F
storage temp.	Store below +30°C.
solubility	2.87g/l
pka	13.17±0.46(Predicted)
form	Liquid
color	Clear colorless
PH	4.46 at 24.3℃ and 10g/L
Water Solubility	immiscible
BRN	607635
LogP	2.4 at 30℃ and pH7.93
CAS DataBase Reference	133-13-1(CAS DataBase Reference)
NIST Chemistry Reference	Propanedioic acid, ethyl-, diethyl ester(133-13-1)
EPA Substance Registry System	Propanedioic acid, ethyl-, diethyl ester (133-13-1)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	2
TSCA	Yes
HS Code	29171990
Toxicity	LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rat > 2000 mg/kg

MSDS Information

Provider	Language
Diethyl ethylmalonate	English
ACROS	English
SigmaAldrich	English
ALFA	English

Diethyl ethylmalonate Usage And Synthesis

Chemical Properties	CLEAR COLOURLESS LIQUID
Uses	Diethyl Ethylmalonate is used in the synthesis of HIV-1 reverse transcriptase inhibitors. Also used in the preparation of Peloruside A, a novel antimitotic agent used as a potential anti-cancer agent.

Diethyl ethylmalonate Preparation Products And Raw materials

Raw materials	Ethanol-->Hydrochloric acid-->Sulfuric acid-->Sodium carbonate-->Sodium cyanide-->Malonic acid-->Chloroacetic acid
Preparation Products	3-(AMINOMETHYL)PENTANENITRILE-->Diethyl isopropylmalonate-->ETHYLMALONIC ACID-->2-ETHYLACRYLIC ACID 98-->DIETHYL SEC-BUTYLMALONATE-->Butanoic acid, 2-(hydroxyimino)-, (E)- (9CI)-->5-Ethyl-5-(4-fluorobutyl)barbituric acid-->ODRGILDUWDVBJX-GKOSEXJESA-N-->3-Ethyl-4-hydroxy-1-Methylquinolin-2(1H)-one

Diethyl ketomalonate Diethyl dibutylmalonate Diethyl 2-ethyl-2-phenylmalonate Diethyl isopropylmalonate Diethyl phenylmalonate Diethyl bis(hydroxymethyl)malonate 2-AMINODIETHYLMALONATE Diethyl butylmalonate Diethyl oxalate DIETHYL DIETHYLMALONATE Diethyl ether DIETHYL DIMETHYLMALONATE Mefenpyr-diethyl DIETHYL ETHYLPHOSPHONATE Celiprolol Diethyl malonate Ethylene glycol diethyl ether Ethyl malonyl chloride

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