Ethyl 2-chloropropionate

Ethyl 2-chloropropionate Basic information
Product Name:Ethyl 2-chloropropionate
Synonyms:2-CHLOROPROPIONIC ACID ETHYL ESTER;ETHYL 2-CHLOROPROPIONATE;ETHYL ALPHA-CHLOROPROPIONATE;2-chloropropanoicacid,ethylester;2-chloro-propanoicaciethylester;ethyl2-chloropropanoate;Propanoic acid, 2-chloro-, ethyl ester;Propanoicacid,2-chloro-,ethylester
CAS:535-13-7
MF:C5H9ClO2
MW:136.58
EINECS:208-610-0
Product Categories:API Intermediate;C2 to C5;Carbonyl Compounds;Esters
Mol File:535-13-7.mol
Ethyl 2-chloropropionate Structure
Ethyl 2-chloropropionate Chemical Properties
Boiling point 146-149 °C (lit.)
density 1.072 g/mL at 25 °C (lit.)
refractive index n20/D 1.417(lit.)
Fp 101 °F
storage temp. Flammables area
solubility alcohol: miscible
form clear liquid
color Colorless to Light yellow
Specific Gravity1.085 (20/4℃)
Water Solubility immiscible
Merck 14,3785
BRN 773906
LogP1.382 (est)
CAS DataBase Reference535-13-7(CAS DataBase Reference)
NIST Chemistry ReferenceEthyl 2-chloropropionate(535-13-7)
EPA Substance Registry SystemEthyl-2-chloropropionate (535-13-7)
Safety Information
Hazard Codes Xi
Risk Statements 10-36/37/38
Safety Statements 26-36-37/39-16
RIDADR UN 2935 3/PG 3
WGK Germany 3
TSCA Yes
HazardClass 3
PackingGroup III
HS Code 29159000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Ethyl 2-chloropropionate Usage And Synthesis
Chemical PropertiesEthyl-2-chloropropionate is a liquid with a pleasant odor
Chemical Propertiesclear colorless liquid
UsesEthyl 2-chloropropionate was used as initiator during the synthesis of poly(2-(diethylamino)ethyl methacrylate) and poly(N-isopropylacrylamide) via atom transfer radical polymerization. It was also used in the synthesis of end-functionalized poly(N-isopropylacrylamide) with pyrenyl group.
General DescriptionA clear colorless liquid with a pungent odor. Flash point of 100°F. Denser than water and insoluble in water. Vapors are heavier than air.
Air & Water ReactionsHighly flammable. Insoluble in water.
Reactivity ProfileEthyl 2-chloropropionate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Health HazardMay cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire HazardHIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Potential ExposureThis material is used in organic synthesis.
ShippingUN2935 Ethyl 2-chloropropionate, Hazard Class: 3; Labels: 3-Flammable liquid.
IncompatibilitiesFlammable liquid; forms explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition. Esters react with acids releasing heat in addition to alcohols and acids. Contact with caustic solutions generate heat. Contact with esters with alkali metals and hydrides releases flammable hydrogen.
3-CYCLOHEXENE-1-CARBOXYLIC ACID METHYL ESTER ETHYL 2-CHLORO-3-OXO-3-PHENYLPROPANOATE ETHYL ALPHA-CHLOROPHENYLACETATE ETHYL 3-CHLOROPROPIONATE, (3-CHLOROPROPIONIC ACID ETHYL ESTER 1-methyl-2-(2-methylpropoxy)ethyl 2-chloropropionate Ethyl (S)-(-)-Chloropropionate Beclomethasone dipropionate ETHYL 2-CHLOROPROPIONATE, (2-CHLOROPROPIONIC ACID ETHYL ESTER) ETHYL 2-CHLOROTETRAFLUOROPROPIONATE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-ISOCYANATOPROPANOATE DIETHYL ETHYLCHLOROMALONATE Clobetasol propionate ETHYL3-CHLOROPROPIONATE, (3-CHLOROPROPIONICACIDETHYL ESTER) METHYL 2-(2-CHLORO-3-ETHOXY-1-METHYL-3-OXOPROPYLIDENE)HYDRAZINE-1-CARBOXYLATE ETHYL 2-CHLOROPROPIONATE, (2-CHLOROPROPIONIC ACID ETHYL ESTE ETHYL-2,3-DICHLOROPROPIONATE (S)-Isobutyl-2-chloropropanoate ETHYL 3-CHLOROPROPIONATE, (3-CHLOROPROPIONIC ACID ETHYL ESTER)

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