1-Deoxynojirimycin

1-Deoxynojirimycin Basic information
Chemical Name Alkaloids
Product Name:1-Deoxynojirimycin
Synonyms:(2r,3r,4r,5s)-2-hydroxymethyl-3,4,5-trihydroxypiperidine;5-piperidinetriol,2-(hydroxymethyl)-,(2r-(2alpha,3beta,4alpha,5beta))-4;bay-h5595;moranolin;moranoline;(+)-1-DEOXYNOJIRIMYCIN;1-DEOXYNOJIRIMYCIN;(2R,3R,4R,5S)-2-(HYDROXYMETHYL)-3,4,5-PIPERIDINETRIOL
CAS:19130-96-2
MF:C6H13NO4
MW:163.17
EINECS:606-239-2
Product Categories:chemical reagent;pharmaceutical intermediate;All Inhibitors;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products;Glycosidase Inhibitors;Inhibitors;Miscellaneous Enzyme
Mol File:19130-96-2.mol
1-Deoxynojirimycin Structure
1-Deoxynojirimycin Chemical Properties
Melting point 195-196°C
Boiling point 361.1±42.0 °C(Predicted)
density 1.456±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
RTECS TN4350300
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in Water up to 25 mg/ml).
pka13.77±0.70(Predicted)
form Powder
color White
Water Solubility Soluble in water, dimethyl sulfoxide and methanol.
BRN 3588039
Stability:Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
LogP-1.8
CAS DataBase Reference19130-96-2(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 1
HS Code 29329990
MSDS Information
1-Deoxynojirimycin Usage And Synthesis
Chemical Name(2R,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
Alkaloids1-deoxynojirimycin  is referred DNJ for short  , it is an alkaloid extracted from the bark of mulberry leaves and roots, but it also exists in other plants and microorganisms. This product is an effective α-glucosidase inhibitor, it has significant hypoglycemic effect. After 1-deoxynojirimycin goes into the human body, it can inhibit sucrose, maltase, α-glucosidase enzyme, α-amylase decomposing  starch, sugar in the human body , thereby it can block the body's absorption of sugar, inhibiting blood sugar rising to achieve the effect of prevention and treatment of diabetes, the use of it does not cause changes in diet . In addition, DNJ can inhibit glucose modification process of HIV tunica glycoprotein , at the same time, the accumulation of immature glycoproteins may inhibit cell fusion, viral and host cell receptor can combine,which causes  syncytia formation to inhibit the replication of  MoLV ,then the virus activity is inhibited.
Nojirimycin is first discovered from Streptomyces, and natural DNJ is first isolated from the bark of mulberry root. In plants, from mulberry, dayflower, hyacinth and Adenophora plants, DNJ has been isolated and identified ,  DNJ has the highest content in the mulberry and because of mulberry varieties, medicinal parts, seasonal climate, geography, soil, leaf position, different developmental stages  and other factors , there is a big difference. In a microorganism, from a variety of Streptomyces and Bacillus,DNJ is isolated ,it is also found that two kinds of endophytes separated from Mulberry including Stenotrophomonas oligotrophic Pseudomonas and Micrococcus can produce DNJ,fermentation conditions of a variety of  microbial production of DNJ are studied. In insects, in addition to silkworm rich in DNJ , single or oligophagous insects with eating mulberry leaves habit including wild silkworm, mulberry geometrid, Diaphania pyloalis Walker , mulberry white capterpillar are also rich in DNJ , DNJ in insects bodies are from the food , content of DNJ in Bombyx bodies is different due to the different varieties of silkworm, developmental stages, tissues and organs as well as feed and other factors, with the silkworm age of progress ,there is the existence of cyclical changes in absorption and accumulation and excretion of DNJ. Now DNJ biosynthetic pathways in Streptomyces, Bacillus and Commelina bodies are explored and it is found that  synthesis of DNJ has different mechanisms in different species . In addition, three main synthesis methods of 1-deoxynojirimycin are proven , some of the synthetic derivatives of DNJ have been used clinically.
Recent studies show that the active ingredient of mulberry DNJ (l-deoxynojirimycin), only exists in mulberry leaves , by blocking the α-glucosidase enzymes to hinder sugar  becoming to glucose, mulberry leaf extract can inhibit intestinal glucose absorption. This can suppress the blood sugar level and blood pressure rising , and it can have good inhibitory effect on variability of imidazopyridine, benzopyrene and other carcinogenic substances,it has anti-cancer effect, at the same time ,mulberry leaf extract can reduce cholesterol, and improve liver function and eliminate constipation and so on.

DescriptionDeoxynojirimycin (19130-96-2) inhibits α-glucosidase I and II.1,2 Inhibits human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step.3 May be used to produce an affinity ligand for purifying glucosidase 1.4 Deoxynojirimycin was used to inhibit ER glucosidases I and II allowing for the discovery of a second mechanism for deglucosylation of N-linked oligosaccharides in PhaR1.7, a mouse lymphoma cell line.5
Chemical PropertiesWhite Crystalline Solid
UsesDeoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase.
UsesAn inhibitor of α-glucosidase I and II
UsesAn alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.
DefinitionChEBI: An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
Biological ActivityInhibitor of glucosidase I (K i = 2.1 mM) and II (K i = 7 mM).
storage+4°C
References1) Fuhrmann et al. (1985), Inhibitors of oligosaccharide processing; Biochim. Biophys, Acta, 825 95 2) Hughs and Rudge (1994), Deoxynojirimycin: synthesis and biological activity; Nat. Prod. Rep., 11 135 3) Papandreou et al. (2002), The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step; Mol. Pharmacol., 61 186 4) Hettkamp et al. (1984), Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides; Eur. J. Biochem., 142 85 5) Suh et al. (1992), Identification of a novel mechanism for the removal of glucose residues from high mannose-type oligosaccharides; J. Biol. Chem., 267 21671
1-Deoxynojirimycin Preparation Products And Raw materials
Triacetonediamine CAMIGLIBOSE Azithromycin N-(7-Oxadecyl)deoxynojirimycin Diphenoxylate Piperidine Clindamycin Trichloroethylene Chlortetracycline NOJIRIMYCIN-1-SULFONIC ACID 4-O-α-D-Glucopyranosyl-1-deoxynojirimycin Minocycline hydrochloride Gentamicin Haloperidol 1-Deoxynojirimycin DROPERIDOL Oxytetracycline dihydrate Cephalothin sodium

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