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Triethyl 2-fluoro-2-phosphonoacetate

Triethyl 2-fluoro-2-phosphonoacetate Basic information
Product Name:Triethyl 2-fluoro-2-phosphonoacetate
Synonyms:2-FLUORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER 95+%;RIETHYL2-FLUORO-2-PHOSPHONOACETATE;2-Fluoro-2-(diethoxyphosphinyl)acetic acid ethyl ester;Fluoro(diethoxyphosphinyl)acetic acid ethyl ester;Diethyl [(ethoxycarbonyl)fluoromethyl]phosphonate 96%;Ethyl (diethoxyphosphonyl)(fluoro)acetate, 2-Fluoro-2-phosphonoacetic acid triethyl ester;(Diethoxyphosphinyl)fluoroacetic Acid Ethyl Ester Ethyl (Diethoxyphosphinyl)fluoroacetate 2-Fluoro-2-phosphonoacetic Acid Triethyl Ester;Triethyl α-fluoro(phosphono)acetate
CAS:2356-16-3
MF:C8H16FO5P
MW:242.18
EINECS:627-648-2
Product Categories:Phosphorus compounds;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Horner-Emmons Reaction;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
Mol File:2356-16-3.mol
Triethyl 2-fluoro-2-phosphonoacetate Structure
Triethyl 2-fluoro-2-phosphonoacetate Chemical Properties
Boiling point 75 °C0.01 mm Hg(lit.)
density 1.194 g/mL at 25 °C(lit.)
refractive index n20/D 1.425(lit.)
Fp 165 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form clear liquid
Specific Gravity1.194
color Colorless to Almost colorless
BRN 1912161
CAS DataBase Reference2356-16-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,F
Risk Statements 36/37/38
Safety Statements 26-36-37/39
WGK Germany 3
F 10-21
Hazard Note Irritant
HazardClass IRRITANT, FLAMMABLE
HS Code 29319090
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Triethyl 2-fluoro-2-phosphonoacetate Usage And Synthesis
Chemical Propertiesclear colorless liquid
UsesReactant for:
  • Diels-Alder reactions
  • Biosynthesis of terpene
  • Stereoselective synthesis of unsaturated esters, fluorides and nitriles from the reactions of aldehydes and ketones using Wadsworth-Emmons phosphonates
  • Synthesis of quinolones
  • Horner-Wadsworth-Emmons asymmetric hydration
  • Addition reactions and the subsequent application to click chemistry
  • Asymmetric intermolecular Stetter reactions
Synthesis Reference(s)The Journal of Organic Chemistry, 60, p. 4730, 1995 DOI: 10.1021/jo00120a014
Triethyl 2-fluoro-2-phosphonoacetate Preparation Products And Raw materials
Raw materialsDIETHYL (DIBROMOFLUOROMETHYL)PHOSPHONATE, 98-->Ethyl bromofluoroacetate-->ETHYL IODOFLUOROACETATE
Triethyl 2-chloro-2-phosphonoacetate TRIETHYL PHOSPHONOACETATE Fluorine Triethyl phosphate Ethyl bromodifluoroacetate Ethyl fluoroacetate Triethyl phosphonoacetate ARSENIC ACID TRIETHYL ESTER diethylphosphonofluoroacetic acid Ethyl trifluoroacetate Ethyl phenylacetate Trimethyl phosphonoacetate Ethyl bromoacetate ETHOXYHYDROXYPHOSPHINYLACETIC ACID Ethyl dimethylphosphonoacetate Triethyl 2-fluoro-2-phosphonoacetate Methyl diethylphosphonoacetate DIETHYLPHOSPHONOACETIC ACID
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