Halcinonide

Halcinonide Basic information
Outline Physical and Chemical Properties Pharmacological effects Indications Adverse reactions Contraindications Precautions Specification Uses
Product Name:Halcinonide
Synonyms:20-dione,21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy-pregn-4-ene-cyc;halciderm;halcimat;Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-beta,16-alpha,17-trihydroxy, cyclic-16,17-acetal with acetone;Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-;21-Chloro-9α-fluoro-11β-hydroxy-16α,17α-(isopropylidenebisoxy)pregn-4-ene-3,20-dione;Halcinonide (200 mg);(11β,16α)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)] pregn-4-ene-3,20-dione
CAS:3093-35-4
MF:C24H32ClFO5
MW:454.96
EINECS:221-439-6
Product Categories:API;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid Hormones;Organics;Cortisone;Hormones
Mol File:3093-35-4.mol
Halcinonide Structure
Halcinonide Chemical Properties
Melting point 264-265° (dec)
alpha D25 +155° (CHCl3)
Boiling point 564.3±50.0 °C(Predicted)
density 1.1567 (estimate)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka13.19±0.70(Predicted)
color White to Off-White
CAS DataBase Reference3093-35-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 63
Safety Statements 36
WGK Germany 3
RTECS TU5010200
HS Code 2937220000
ToxicityLD50 i.p. in mice: 150 mg/kg (Millonig, Yiakas)
Halcinonide Usage And Synthesis
OutlineHalcinonide is an efficient synthetic fluorine and chlorine corticosteroid, the effect of it is similar to fludrocortisone . It has strong anti-inflammatory, anti-allergic, anti-itching, inhibiting proliferation of immune effects, topical application can reduce the permeability of the capillary wall and cell membrane,and reduce the inflammatory exudate, and inhibit histamine and other inflammatory mediators formation and release.it is clinically used for subacute or chronic non-infectious skin diseases such as psoriasis, eczema, neurodermatitis, contact dermatitis, seborrheic dermatitis (non-face), atopic dermatitis, flat moss and discoid lupus erythematosus and the like which are hormone therapy ineffective .
Physical and Chemical PropertiesWhite or off-white crystalline powder, odorless. Almost insoluble in water, slightly soluble in ethanol or methanol, soluble in acetone and chloroform. Sealed.



Pharmacological effectsThis drug is a potent synthetic glucocorticoid ,its action is similar to fludrocortisone. It has strong anti-inflammatory, anti-allergic, anti-itching, inhibit proliferation of immune and other effects, topical application are unlikely to cause systemic adverse reactions. The drug has the same effect of inhibiting the proliferation of granulation tissue as dexamethasone ,it is stronger than hydrocortisone. The drug is not substantially absorbed in external skin, it has no irritating effect on the body. The extent of absorption of topical application is hugely different among anatomic sites: forearm 1%, 4% of the scalp, forehead, 7%, 36% of the scrotum, the greatest penetration is in the groin, armpits and face. The drug is mainly metabolized in the liver, it is mostly excreted by the kidneys, and less by biliary excretion.
The above information is edited by the chemicalbook of Tian Ye.
IndicationsThe drug is suitable for treatment of contact dermatitis, atopic dermatitis, lichen,the small size of psoriasis, lichen, heat rash, genital atrophic lichen sclerosus, non-parasitic prurigo, ring granuloma, discoid lupus erythematosus, non-facial seborrheic dermatitis, mycosis fungoides pruritus symptomatic .It is also used for the treatment of insect bites, parasitic prurigo through specific treatment. It has a good effect on the treatment of psoriasis .
Adverse reactions 1. There are a small number of patients whose applicator parts of the skin occurs burning, stinging, itching temporary, long-term use can occur telangiectasia skin (especially face), skin atrophy, stretch marks (teenagers prone), fragile skin, hirsutism, folliculitis, milia, skin bleaching, delayed ulcer healing, packet method in skin folds easily causes fungal infection.
2. When it is much absorbed through the skin, it can cause systemic adverse reactions.
Contraindications1.Patients who are allergic to this drug and adrenal corticosteroids are banned.
2. The primary skin diseases , exudative dermatitis, ulcerative lesions, acne, rosacea caused by bacteria, fungi, viruses and parasites are banned.
3. It is forbidden using in the eyelid portion (cause a risk of glaucoma).

Precautions1. The large area of large quantities of drugs or medication packet mode allow more amount of the drug being absorbed through the skin, which causes systemic reactions, especially in young children and infants, it can cause reversible Cushing's syndrome and growth retardation, sudden withdrawal can cause acute adrenal insufficiency.
2. When the local intolerance phenomena occurs,the drug should be stopped and the reason should be found.
3. It should be paid attention that drug staying in the skin folds and diaper can be absorbed into the body.

SpecificationOintments, creams, solutions: 0.1%.
UsesCortical hormone drugs for the treatment of psoriasis and eczema dermatitis .
OriginatorHalog,Squibb,US,1974
Uses2H-Naphth[2'',1'':4,5]indeno[1,2-d][1,3]dioxole Pregn-4-ene-3,20-dione Deriv. is a by-product from the synthesis of 4-Fluorotriamcinolone Acetonide (F598640) an analog of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.
UsesAnti-inflammatory (topical).
DefinitionChEBI: Halcinonide is an organic molecular entity. It has a role as a SMO receptor agonist.
IndicationsHalcinonide (Halog, Halog-E) is a synthetic fluorinated corticosteroid.
Manufacturing Process(A) 16α-Hydroxy-9α-fluorohydrocortisone acetonide 27-mesylate: To a solution of 1.5 g of 16α-hydroxy-9α-fluorohydroortisone acetonide in 15 ml of dry pyridine is added at 0°C. 1.5 ml of methane-sulfonyl chloride. After standing in the refrigerator for 2,5 hours, excess methanesulfonyl chloride is destroyed by the addition of a small amount of ice, after which ice-water is added slowly to precipitate the reaction product. After ? hour in the refrigerator the material is filtered off, washed thoroughly with water and dried in vacuo. The resulting crude material after recrystallization from acetone-hexane gives the pure 21-mesylate of the following properties: melting point about 225°C to 227°C (decomposition); [α]D23+112° (c, 0.5 in chloroform).
(B) 21-Chloro-9α-fluoro-δ4-pregnene-11β,16α,17α-triol-3,20-dione16,17- acetonide : A solution of 200 mg of the acetonide 21-mesylate from part (A) and 900 mg of lithium chloride in 25 ml of dimethylformamide is kept at 100°C for 24 hours. The mixture is poured on ice, extracted with chloroform and the chloroform extract washed with water and dried over sodium sulfate. Evaporation of the solvent in vacuo furnishes the crystalline chloride, which after recrystallization from acetone-ethanol has a melting point about 276°C to 277°C.
Brand nameHalog (Bristol-Myers Squibb); Halog (Westwood-Squibb).
Therapeutic FunctionTopical corticosteroid
General DescriptionHalcinonide, 21-chloro-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, was the first chloroGC marketed. Likemany other potent GCs, it is used only topically.
Halcinonide-Dihydroxy Ethanone, 2-chloro-1-cyclopentyl- (9CI) Fluorine p-(2-Methoxyethyl) phenol 1-Chlorohexadecane 3-Diethylaminophenol 1-Chlorooctadecane Chlorine 2,2-Dimethyl-4-hexyl-1,3-dioxolane Difluorochloromethane Flugestone 6(R),7-ISOPROPYLIDENE-HEPTANOL HALCINONIDE USP(CRM STANDARD) 1-Chloro-3-isopropoxypropane Halcinonide 4-Chloro-2-methyl-2-butanol CHLOROPHOSPHONAZO III

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.