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| | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Basic information |
| Product Name: | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE | | Synonyms: | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE;MELPHALAN HCL;MELPHALAN HYDROCHLORIDE;phenylalaninemustardhydrochloride;Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1);2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANOIC ACID HYDROCHLORIDE (MELPHALAN HYDROCHLORIDE);(S)-3-[4-[Bis(2-chloroethyl)amino]phenyl]alanine hydrochloride;Melphalan Hydrochloride (100 mg) (International Restricted Sales Item) | | CAS: | 3223-07-2 | | MF: | C13H19Cl3N2O2 | | MW: | 341.66 | | EINECS: | 643-091-8 | | Product Categories: | | | Mol File: | 3223-07-2.mol |  |
| | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Chemical Properties |
| Melting point | 175-178 °C | | solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Moisture Sensitive |
| Toxicity | TDLo orl-hmn: 1200 mg/kg/5D-I:GIT CCROBU57,369,73 |
| | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug. | | Safety Profile | Deadly poison by intravenousroute. Human systemic effects by ingestion: nausea andvomiting. Questionable carcinogen with experimentalcarcinogenic data. When heated to decomposition it emitsvery toxic fumes of Cl-, NOx, and HCl. |
| | 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Preparation Products And Raw materials |
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