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| | 2-hydroxypropyl-α-cyclodextrin Basic information |
| | 2-hydroxypropyl-α-cyclodextrin Chemical Properties |
| Melting point | 245 °C (dec.)(lit.) | | density | 1.39 at 24.6℃ | | solubility | Soluble in water, methanol, DMF. Insoluble in acetone, chloroform. | | form | Solid powder | | color | White to off white | | optical activity | [α]20/D +125°, c = 1 in H2O | | LogP | -10.6--9.89 | | Surface tension | 66.1mN/m at 1g/L and 20℃ | | EPA Substance Registry System | .alpha.-Cyclodextrin, 2-hydroxypropyl ethers (128446-33-3) |
| | 2-hydroxypropyl-α-cyclodextrin Usage And Synthesis |
| Uses | - (2-Hydroxypropyl)-α-cyclodextrin can be used as a chiral selector to resolve tryptophan racemate by capillary electrophoresis.
- It can be used to synthesize biodegradable polyrotaxanes for fabricating blood-contacting devices.
- Co-polymer based on (2-hydroxypropyl)-α-cyclodextrin cross-linked with polyethylenimine can be used as a gene delivery vector.
- It can also be used as stabilizer for antibacterial iodine formulations, as it forms a stable inclusion complex with iodine and improves aqueous solubility.
| | General Description | (2-Hydroxypropyl)-α-cyclodextrin is a hydroxyalkyl derivative of cyclodextrin, which is generally used as a substitute of α-cyclodextrin for potential application in food, cosmetics and pharmaceutical industries. It may be used as a parenteral drug carrier on account of its attractive characteristics such as: a greater extent of solubility in water, high dissolution capacity for weakly soluble analytes, and low toxicity. |
| | 2-hydroxypropyl-α-cyclodextrin Preparation Products And Raw materials |
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