Squalene

Squalene Basic information
Product Name:Squalene
Synonyms:2,6,10,15,19,23-HEXAMETHYL-2, 6, 10, 14, 18, 22-TETRACOSAHEXENE;(all-e)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene;(E,E,E,E)-Squalene;2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene;2,6,10,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexane;2,6,10,15,19,23-Hexamethyltetracosahexa-2,6,10,14,18,22-ene;6,10,14,18,22-Tetracosahexaene,2,6,10,15,19,23-hexamethyl-,(all-E)-2;All-trans-Squalene
CAS:111-02-4
MF:C30H50
MW:410.72
EINECS:203-826-1
Product Categories:Biochemistry;Terpenes;Terpenes (Others);Triterpenoids
Mol File:111-02-4.mol
Squalene Structure
Squalene Chemical Properties
Melting point −75 °C(lit.)
Boiling point 285 °C25 mm Hg(lit.)
density 0.858 g/mL at 25 °C(lit.)
vapor pressure 0Pa at 25℃
refractive index n20/D 1.494(lit.)
Fp >230 °F
storage temp. 2-8°C
solubility DMSO : 16.67 mg/mL (40.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form liquid
color light yellow
Odoroil, faint odor
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 14,8768
BRN 1728919
LogP14.12 at 24℃
CAS DataBase Reference111-02-4(CAS DataBase Reference)
NIST Chemistry Reference2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-(111-02-4)
EPA Substance Registry SystemSqualene (111-02-4)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS XB6010000
8-10-23
TSCA Yes
HS Code 29012980
Hazardous Substances Data111-02-4(Hazardous Substances Data)
Toxicitymouse,LD50,intravenous,1800mg/kg (1800mg/kg),Japanese Journal of Cancer Research. Vol. 76, Pg. 1021, 1985.
MSDS Information
Squalene Usage And Synthesis
Chemical Propertiesclear colourless to faint yellow oil
UsesSqualene is a natural triterpene that plays an important role in the synthesis of cholesterol, steroid hormones, and vitamin D in the human body. Squalene is commonly used as a biochemical precursor i n the preparation of steroids. Squalene is also a natural moisturizer with low acute toxicity and is not significant human skin irritants or sensitizers.
Usescosmetic and pharmaceutical excipient
UsesBactericide; intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents.
DefinitionChEBI: A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.
General DescriptionClear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.
Air & Water ReactionsMay become discolored on exposure to air. Insoluble in water.
Reactivity Profile(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is incompatible with strong oxidizing agents. .
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition (all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene emits toxic fumes of carbon monoxide and carbon dioxide.
Fire Hazard(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is probably combustible.
Flammability and ExplosibilityNonflammable
Biochem/physiol ActionsSqualene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high density lipoprotein) and the excretion of LDL (low density lipoprotein). This helps in reducing the risk of heart disease and protects the less stable body fats from oxidation. It is also used in treating hypercholesterolemia. Squalene is known to improve the efficiency of cholesterol lowering drugs. It also serves as an antioxidant by preventing the effects of free radical. It protects skin from drying and other environmental conditions such as oxidation, ultraviolet rays and pollutants. Squalene is known to promote wound healing.
targetCOX | STAT | FOXP3 | Nrf2 | SOD | GPx
CEPHALIN Fullerene C70 hydroxygenkwanin beta-Eudesmol syn-coll 1,5,9-DECATRIENE TRIISOBUTYLENE 2,7-dimethyl-2,6-octadiene 2,6,10,15,19,23-HEXAMETHYL-2,6,10,14,18,22-TETRACOSAHEXAENE SQUALENE, [1,5,9,14,20,24-14C] 3,7-DECADIENE 6-METHYL-1,5-HEPTADIENE 2 6-DIMETHYL-2 CIS-6-OCTADIENE Squalane SQUALENE, [4,8,12,13,17,21-3H] Squalene 2,6-OCTADIENE 1,5,9,13-TETRADECATETRAENE Squalene Oil

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