BACMECILLINAM

BACMECILLINAM Basic information
Product Name:BACMECILLINAM
Synonyms:BACMECILLINAM;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, 1-[(ethoxycarbonyl)oxy]ethyl ester, (2S,5R,6R)-;BACMECILLINAM USP/EP/BP
CAS:50846-45-2
MF:C20H31N3O6S
MW:441.54
EINECS:
Product Categories:
Mol File:50846-45-2.mol
BACMECILLINAM Structure
BACMECILLINAM Chemical Properties
Boiling point 256°C (rough estimate)
density 1.2025 (rough estimate)
refractive index 1.6390 (estimate)
color Oil
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
MSDS Information
BACMECILLINAM Usage And Synthesis
OriginatorBacmecillinam,ZYF Pharm Chemical
Manufacturing Process1-Hexamethyleneiminocarboxaldehyde dimethylacetate (3.1 g) in chloroform (50 ml) was added dropwise at -30°C to a solution of 1’- ethoxycarbonyloxyethyl 6-aminopenicillanate (5.0 g) and triethylamine (1.9 ml) in chloroform (150 ml) during 15 min. Then, the temperature is allowed to rise to 0°C during 30 min, and the mixture is stirred at 0°C for another 60 min. Water (120 ml) is added, and stirring is continued for 10 min. The water phase is separated and the organic layer is washed with water and stripped. There was obtained 5.0 g of the 1’-ethoxycarbonyloxy-ethyl 6-(hexahydro-1Hazepin- l-yl) methyleneaminopenicillanate.
Therapeutic FunctionAntibiotic
Safety ProfileAn experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of SOx and NOx.
BACMECILLINAM Preparation Products And Raw materials
Raw materialsTriethylamine
TRIMETHYLAMMONIUM FORMIATE 4-METHOXY-2-METHYL-2-BUTANETHIOL Mecillinam ETHYL 3-(METHYLTHIO)BUTYRATE BACMECILLINAM

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