ChemicalBook Product Catalog Biochemical Engineering Condensing agent 1-Hydroxybenzotriazole hydrate

1-Hydroxybenzotriazole hydrate

1-Hydroxybenzotriazole hydrate Basic information
Product Name:1-Hydroxybenzotriazole hydrate
Synonyms:HOBTM;HOBT HYDRATE;HOBT H2O;1H-1,2,3-benzotriazol-1-ol hydrate solution;1-HYDROXYBENZOTRIAZOLE 15 WT. % SOLUTI&;1H-Benzo[d][1,2,3]triazol-1-ol xhydrate;1H-benzo[d][1,2,3]triazol-1-ol hydrate;HOBT.H2O1-Hydroxybenzotriazole hydrate
CAS:123333-53-9
MF:C6H7N3O2
MW:153.14
EINECS:602-929-2
Product Categories:Heterocyclic Compounds;Peptide;FINE Chemical & INTERMEDIATES;Heterocycles;Bases & Related Reagents;Nucleotides;123333-53-9
Mol File:123333-53-9.mol
1-Hydroxybenzotriazole hydrate Structure
1-Hydroxybenzotriazole hydrate Chemical Properties
Melting point 155-158 °C(lit.)
Boiling point 248.8°C (rough estimate)
density 1.065 g/cm
refractive index 1.6910 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMF: 100 mg/mL, clear
form Solid
color White to Off-White
Water Solubility slightly soluble
BRN 4515
Stability:Hygroscopic
CAS DataBase Reference123333-53-9(CAS DataBase Reference)
Safety Information
Hazard Codes F
Risk Statements 5-11-R5-R11-44-1
Safety Statements 15-16-35-7/9-33-S7/9-S33-S16-60-37-26
RIDADR UN 3380 4.1/PG 1
WGK Germany -
F 4.10-8
Hazard Note Highly Flammable
HS Code 29339980
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
1-Hydroxybenzotriazole hydrate Usage And Synthesis
Chemical PropertiesWhite to off-white powder
Usesadditive for oligonucleotide couplings and in racemization-free peptide couplings
Uses1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:
  • Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
  • Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

UsesA common additive for peptide coupling.
General Description1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials
Raw materials4-Methylmorpholine
Preparation ProductsCefodizime
Methylparaben Chloral hydrate 2-CLTRT RESIN-LEU-OBT 4-Hydroxybenzoic acid hydrazine hydrate 1-Hydroxybenzotriazole 2'-Hydroxy-3-phenylpropiophenone 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 2-Hydroxyphenylacetic acid BIS(HYDROXYBENZOTRIAZOLYL) CARBONATE 4-Hydroxybenzaldehyde Triclosan 4'-Hydroxyacetophenone 4-Methoxyphenol 4-Hydroxy-D-(-)-2-phenylglycine 1-Hydroxybenzotriazole hydrate hydrate FMOC-OBT
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