ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Urine (urea) pyrimidine 5-Iodouracil

5-Iodouracil

5-Iodouracil Basic information
Product Name:5-Iodouracil
Synonyms:2,4-DIHYDROXY-5-IODOPYRIMIDINE;5IU;5-IODOURACIL;5-IODO-1H-PYRIMIDINE-2,4-DIONE;5-IODO-2,4-(1H,3H)-PYRIMIDINEDIONE;TIMTEC-BB SBB009920;5-Iodouracil,97%;2,4(1H,3H)-Pyrimidinedione, 5-iodo-
CAS:696-07-1
MF:C4H3IN2O2
MW:237.98
EINECS:211-788-2
Product Categories:Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids
Mol File:696-07-1.mol
5-Iodouracil Structure
5-Iodouracil Chemical Properties
Melting point 274-276 °C (dec.) (lit.)
density 2.2076 (estimate)
storage temp. 2-8°C
solubility Very faint turbidity in NH3aq. Soluble in 1M NaOH.
pka7.02±0.10(Predicted)
form Fluffy Powder
color White to light yellow
Water Solubility SOLUBLE IN COLD WATER
Sensitive Light Sensitive
BRN 4891
CAS DataBase Reference696-07-1(CAS DataBase Reference)
NIST Chemistry Reference5-Iodouracil(696-07-1)
EPA Substance Registry System2,4(1H,3H)-Pyrimidinedione, 5-iodo- (696-07-1)
Safety Information
Hazard Codes T,Xi
Risk Statements 46-20/21/22-36/37/38
Safety Statements 53-22-26-36/37/39-45
RIDADR 2811
WGK Germany 3
RTECS YR0525000
Hazard Note Irritant/Carcinogenic/Light Sensitive
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29335990
MSDS Information
ProviderLanguage
2,4-Dihydroxy-5-iodopyrimidine English
SigmaAldrich English
ACROS English
ALFA English
5-Iodouracil Usage And Synthesis
Chemical Propertieswhite to light yellow fluffy powder
Uses5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studie s show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
Uses5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studies show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
DefinitionChEBI: An organoiodine compound consisting of uracil having an iodo substituent at the 5-position.
5-Iodouracil Preparation Products And Raw materials
Preparation Products2,4(1H,3H)-Pyrimidinedione, 5-(3-pyridinyl)--->NSC 54274
5-IODO-1,3-DIMETHYLURACIL 5-IODO-2',3'-DIDEOXYURIDINE 3'-azido-2',3'-dideoxy-5-iodouridine (5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-ACETIC ACID 1-Hydroxyethylidene-1,1-diphosphonic acid N-blocked-5'-O-DMT 3'-CED iododeoxyuridine phosphoramidite 5-IODOURACIL, [2-14C]- IODODEOXYURIDINE, [125I] 1,3-Dihydroxyacetone 5-IODO-URIDINE-5'-TRIPHOSPHATE, SODIUM SALT Idoxuridine 3,5-Dihydroxybenzoic acid (S)-(-)-5-IODOWILLARDIINE 5-IODO 2'-DEOXYURIDINE, [6-14C]- 5-IODOURIDINE 5'-MONOPHOSPHATE SODIUM SALT 5-IODOURIDINE 5-Iodouracil 3',5'-DIACETYL-5-IODO-2'-DEOXYURIDINE
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