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| | NEOMYCIN B Basic information |
| | NEOMYCIN B Chemical Properties |
| Melting point | >194°C (dec.) | | Boiling point | 658.4°C (rough estimate) | | density | 1.3548 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | 2-8°C | | solubility | Aqueous Acid (Slightly), Water (Slightly) | | form | liquid | | pka | 12.93±0.70(Predicted) | | color | clear | | Merck | 13,6482 | | Stability: | Hygroscopic |
| | NEOMYCIN B Usage And Synthesis |
| Uses | Neomycin C is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. | | Definition | ChEBI: A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. | | General Description | Chemical structure: aminoglycoside | | Biochem/physiol Actions | Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria |
| | NEOMYCIN B Preparation Products And Raw materials |
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