N-NITROSODIETHYLAMINE

N-NITROSODIETHYLAMINE Basic information
Product Name:N-NITROSODIETHYLAMINE
Synonyms:DIETHYLNITROSAMINE;N,N-DIETHYLNITROSOAMINE;1,1-Diethyl-2-oxohydrazine;DANA;DEN;den(mutagen);DENA;Diaethylnitrosamin
CAS:55-18-5
MF:C4H10N2O
MW:102.14
EINECS:200-226-1
Product Categories:Nitrosamine;Mutagenesis Research Chemicals;Nitric Oxide Reagents
Mol File:55-18-5.mol
N-NITROSODIETHYLAMINE Structure
N-NITROSODIETHYLAMINE Chemical Properties
Melting point <25℃
Boiling point 177 °C (lit.)
density 0.95 g/mL (lit.)
vapor pressure 1.7 mmHg at 20 °C
refractive index n20/D 1.437
storage temp. 2-8°C
solubility Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly)
pka-3.14±0.70(Predicted)
form liquid
color yellow
OdorNot available
Water Solubility 106.2g/L(24 ºC)
Merck 6636
BRN 1744991
Stability:Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents.
CAS DataBase Reference55-18-5(CAS DataBase Reference)
IARC2A (Vol. 17, Sup 7) 1987
EPA Substance Registry SystemN-Nitrosodiethylamine (55-18-5)
Safety Information
Hazard Codes T,F
Risk Statements 45-22-39/23/24/25-23/24/25-11
Safety Statements 53-45-36/37-16
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS IA3500000
HazardClass 6.1(b)
PackingGroup III
HS Code 29299090
Hazardous Substances Data55-18-5(Hazardous Substances Data)
ToxicityLD50 oral (rat) 280 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
N-NITROSODIETHYLAMINE Usage And Synthesis
Chemical PropertiesN-Nitrosodiethylamine is a yellow liquid.
UsesN-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.
UsesGasoline and lubricant additive; antioxidant; stabilizer in plastics.
UsesN,N-diethylnitrous Amide is a useful research reagent for organic synthesis.
DefinitionChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
General DescriptionClear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics.
Air & Water ReactionsWater soluble.
Reactivity ProfileN-NITROSODIETHYLAMINE reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid .
HazardPossible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition N-NITROSODIETHYLAMINE emits toxic fumes of nitrogen oxides.
Health HazardThe acute toxicity of diethylnitrosamine is classified as moderate. Other nitrosamines of higher molecular weight are somewhat less toxic. Harmful exposure to nitrosamines can occur by inhalation and ingestion and may cause nausea, vomiting, and fever. This substance does not have adequate warning properties. Chronic exposure to nitrosamines can cause severe liver damage. Diethylnitrosamine is listed in IARC Group 2A ("probable human carcinogen") and is classified as an OSHA "select carcinogen." Nitrosamines are suspected of causing cancers of the lung, nasal sinuses, brain, esophagus, stomach, liver, bladder, and kidney. Diethylnitrosamine is mutagenic and teratogenic.
Fire HazardVolatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Fire HazardN-NITROSODIETHYLAMINE is combustible.
Flammability and ExplosibilityVolatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides.
Biochem/physiol ActionsN-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.
Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and AMINES.
Potential ExposureAn additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
CarcinogenicityN-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
storagework with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact.
ShippingUN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
IncompatibilitiesAn additive in gasoline and lubricants; an antioxidant and stabilizer in plastics. Used in research. Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with reducing agents may form hydrazine; hydrogen bromide. Light sensitive; rapidly decomposes.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Under 40 CFR 261.5 small quantity generators of this waste may qualify for partial exclusion from hazardous waste regulations.
N-Nitrosodibutylamine N,N'-DINITROSOPIPERAZINE 1,1'-Dimethyl-N-nitrosodiethylamine N-TERT-BUTYL-N-ETHYLNITROSAMINE N-nitrosodibenzylamine N-NITROSOETHYL-N-PROPYLAMINE N-NITROSO DICYCLOHEXYLAMINE N-NITROSOMORPHOLINE N-NITROSOPIPERIDINE N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE 1-nitrosopiperazine N,N-DINITROPIPERAZINE N-PROPYL-N-BUTYLNITROSAMINE N-ETHYL-N-BUTAN-4-OL-NITROSAMINE N-NITROSODI-N-PROPYLAMINE 2,2'-dihydroxy-N-nitrosodiethylamine N-NITROSO-B-ETHYLAMINOISOBUTYLETHYL KETONE N-NITROSOPYRROLIDINE

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