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| | Clobetasol Basic information |
| Product Name: | Clobetasol | | Synonyms: | ClobetasolBase;Clobetasol Propionate 25122-46-7 / Base;21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione;CLOBETASOLE PROPIONATE;CLOBETASOL-17-PROPIONATE;CLOBESTASOL PROPIONATE;Clobetasol (Betamethasone Impurity B);(11β,16β)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione | | CAS: | 25122-41-2 | | MF: | C22H28ClFO4 | | MW: | 410.91 | | EINECS: | 246-633-8 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 25122-41-2.mol |  |
| | Clobetasol Chemical Properties |
| Melting point | 220-222°C | | Boiling point | 555.1±50.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 12.03±0.70(Predicted) | | form | Solid | | color | White to Light Brown |
| | Clobetasol Usage And Synthesis |
| Chemical Properties | White to Off-White Solid | | Originator | Dermovate,Glaxo,UK,1973 | | Uses | Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory. | | Uses | Atorvastatin Intermediate | | Definition | ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit
ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis. | | Manufacturing Process | A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide
(25 ml) was treated with lithium chloride (4 g) and the mixture heated on the
steam bath for 30 minutes. Dilution with water gave the crude product which
was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by
reaction with propionic anhydride.
| | Brand name | Clobex (Galderma); Clobex (Galderma);
Embeline (Healthpoint); Olux (Connetics); Temovate
(Altana). | | Therapeutic Function | Corticosteroid, Antiinflammatory |
| | Clobetasol Preparation Products And Raw materials |
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