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| | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Basic information | | Reactions |
| Product Name: | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine | | Synonyms: | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine;2,6-BIS[(4R)-PHENYL-2-(OXAZOLIN-2-YL)]PYRIDINE;(R,R)-2,6-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine;(R,R)-2,6-BIS(4-PHENYL-2-OXAZOLIN-2-YL)PYRIDINE;(r,r)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine;(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-PHENYL-2-OXAZOLINE);[R-(R,R)]-2,6-BIS(4,5-DIHYDRO-4-PHENYL-2-OXAZOLYL)PYRIDINE;(R-(R*,R*))-2,6-bis(4,5-dihydro-4-phenyl-2-oxazol | | CAS: | 128249-70-7 | | MF: | C23H19N3O2 | | MW: | 369.42 | | EINECS: | | | Product Categories: | BOX series;Chiral Nitrogen;Heterocycle-Pyridine series;organic amine;Asymmetric Synthesis;Synthetic Organic Chemistry | | Mol File: | 128249-70-7.mol | ![2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Structure](CAS/GIF/128249-70-7.gif) |
| | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Chemical Properties |
| Melting point | 171-175 °C(lit.) | | alpha | 185 º (c=1, methylene chloride) | | Boiling point | 600.4±55.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 3.07±0.70(Predicted) | | form | crystal | | color | white | | optical activity | [α]22/D 187°, c = 1 in methylene chloride | | Water Solubility | Insoluble | | CAS DataBase Reference | 128249-70-7(CAS DataBase Reference) |
| | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Usage And Synthesis |
| Reactions |
- Ligand for Copper catalyzed syn-selective Mukaiyama aldol reaction.
- Ligand for Tin catalyzed anti-selective aldol reaction.
- Ligand for Ytterbuim catalyzed desymmetrization of meso epoxides.
- Ligand for Copper catalyzed enantioselective addition of terminal alkynes to imines.
- Ligand for Scandium catalyzed enantioselective syn-selective ene reactions.
- Ligand for Copper catalysed asymmetric alkynylation of cyclic azomethine Imines.
- Ligand for Europium catalyzed asymmetric alpha amination.
| | Chemical Properties | White needles | | Uses | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine [Pybox] may be used as a chiral ligand in the copper-catalyzed enatioselective arylation of N-arylated tetrahydroisoquinolines (THIQs) with arylboronic acids in the presence of a photoredox catalyst. |
| | 2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Preparation Products And Raw materials |
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