ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Tyrosine derivatives 3-Nitro-L-tyrosine

3-Nitro-L-tyrosine

3-Nitro-L-tyrosine Basic information
Product Name:3-Nitro-L-tyrosine
Synonyms:(2R)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid;L-Tyrosine, 3-nitro-;3-Nitro-L-tyrosine,99%;(S)-2-aMino-3-(4-hydroxy-3-nitrophenyl)propanoic acid;Z-D-Dap(Boc);3-NITRO-L-TYROSINE (RING-13C6);(S)-3-(3-Nitro-4-hydroxyphenyl)alanine;3-Nitro-L-tyrosine≥ 98% (Assay)
CAS:621-44-3
MF:C9H10N2O5
MW:226.19
EINECS:210-688-6
Product Categories:Pharmaceutical Raw Materials;Amino Acids;Tyrosine [Tyr, Y];Unusual Amino Acids;Oxidative Stress Proteins and ReagentsPeptide Synthesis;Cell Stress;Peptide Synthesis;Tyrosine Derivatives;Unnatural Amino Acid Derivatives;Nitric Oxide and Cell Stress;Amino Acids & Derivatives;Aromatics
Mol File:621-44-3.mol
3-Nitro-L-tyrosine Structure
3-Nitro-L-tyrosine Chemical Properties
Melting point 233-235 °C (dec.) (lit.)
alpha 4 º (c=1, 1N HCl)
Boiling point 367.79°C (rough estimate)
density 1.4160 (rough estimate)
refractive index 1.5373 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Aqueous Acid (Slightly), Water
form crystalline
pka2.17±0.20(Predicted)
color yellow to green
Water Solubility insoluble
BRN 2813157
CAS DataBase Reference621-44-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-37/39-26-36
WGK Germany 3
HS Code 29225090
MSDS Information
ProviderLanguage
3-Nitro-L-tyrosine English
SigmaAldrich English
ACROS English
ALFA English
3-Nitro-L-tyrosine Usage And Synthesis
DescriptionNitrotyrosine is formed by peroxynitrite-mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation in vivo. Both free and protein-bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions. The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.
Chemical Propertiesochre-yellow to yellow-green powder
UsesA marker for peroxynitrite. Oxidant and cytotoxic agent.
Uses3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage.
DefinitionChEBI: 3-nitro-L-tyrosine is a 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and a 3-nitrotyrosine. It is an enantiomer of a 3-nitro-D-tyrosine.
Biochem/physiol ActionsOxidant and cytotoxic agent.
3-Nitro-L-tyrosine Preparation Products And Raw materials
BOC-TYR(BZL, 3-NO2)-OH L-Tyrosine H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH 3-NITRO-L-TYROSINE ETHYL ESTER HYDROCHLORIDE NITROGEN DIOXIDE L-4-HYDROXY-3-NITROPHENYL-5-D1-ALANINE 3-NITRO-L-TYROSINE, [3H]- Boc-D-Tyr-OH 3-Nitro-L-Tyrosine-13C9 FMOC-3,5-DINITRO-TYR-OH N-Acetyl-3,5-dinitro-L-tyrosine TYROSINASE FROM MUSHROOM BIOCHEMIKA, LYOPHILIZED, ≥2000 UNITS/MG (S)-METHYL 3-(4-HYDROXY-3-NITROPHENYL)-2-(2,2,2-TRIFLUOROACETYLAMINO)PROPIONATE FMOC-TYR(BZL,3-NO2)-OH H-TYR(BZL, 3-NO2)-OH 3-Nitro-L-tyrosine (S)-2-AMINO-3-(4-HYDROXY-3-NITRO-PHENYL)-PROPIONIC ACID METHYL ESTER 3,5-DINITRO-L-TYROSINE MONOHYDRATE
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