Propiophenone

Propiophenone Basic information
Description References
Product Name:Propiophenone
Synonyms:1-phenyl-1-propanon;1-phenylpropanone;1-phenylpropanone-1;1-Propanone,1-phenyl-;Ketone, ethyl phenyl;ketone,ethylphenyl;lithylphenyllwton;phenylpropone
CAS:93-55-0
MF:C9H10O
MW:134.18
EINECS:202-257-6
Product Categories:ketone;Purines;Building Blocks;C9;Carbonyl Compounds;Chemical Synthesis;Ketones;Organic Building Blocks;Organics;API intermediates
Mol File:93-55-0.mol
Propiophenone Structure
Propiophenone Chemical Properties
Melting point 17-19 °C(lit.)
Boiling point 218 °C(lit.)
density 1.009 g/mL at 25 °C(lit.)
vapor pressure 1 mm Hg ( 50 °C)
refractive index n20/D 1.526(lit.)
FEMA 3469 | PROPIOPHENONE
Fp 190 °F
storage temp. Store below +30°C.
solubility Difficult to mix.
form Liquid
color Clear colorless to light yellow
Odorat 10.00 % in dipropylene glycol. hawthorn lilac floral aromatic cherry herbal
Odor Typefloral
Water Solubility INSOLUBLE
Merck 14,7830
JECFA Number824
BRN 606215
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKeyKRIOVPPHQSLHCZ-UHFFFAOYSA-N
LogP2.71
CAS DataBase Reference93-55-0(CAS DataBase Reference)
NIST Chemistry Reference1-Propanone, 1-phenyl-(93-55-0)
EPA Substance Registry SystemPropiophenone (93-55-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 2
RTECS UG7175000
TSCA Yes
HS Code 2914 39 00
Hazardous Substances Data93-55-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Propiophenone Usage And Synthesis
DescriptionPropiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.
Referenceshttps://en.wikipedia.org/wiki/Propiophenone
https://pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top
http://www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm
https://www.alfa.com/en/catalog/A15140/

Chemical Propertiescolourless to light yellow liquid
Chemical PropertiesPropiophenone has a strong, flowery odor.
OccurrenceReported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.
UsesIntermediates of Liquid Crystals
UsesIn perfumery; in the synthesis of ephedrine and related Compounds.
UsesPropiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.
Production MethodsPropiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.
DefinitionChEBI: An aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl.
Synthesis Reference(s)The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI: 10.1021/jo00113a024
Tetrahedron Letters, 30, p. 4819, 1989 DOI: 10.1016/S0040-4039(01)80517-7
Flammability and ExplosibilityNotclassified
Safety ProfilePoison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
2',6'-DICHLORO-3-(4-FLUOROPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(3,4,5-TRIFLUOROPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(2-THIOMETHYLPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(4-THIOMETHYLPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(2,3-DIMETHYLPHENYL)PROPIOPHENONE 2'-CARBOETHOXY-3-(3,4,5-TRIFLUOROPHENYL)PROPIOPHENONE 2',6'-DICHLORO-3-(3-TRIFLUOROMETHYLPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(2,5-DIMETHYLPHENYL)PROPIOPHENONE 2',6'-DICHLORO-3-(3-METHYLPHENYL)PROPIOPHENONE PHENYL VALERATE 1-PROPIOPHENONE-P-TOLUENESULFONYLHYDRAZONE,1-PROPIOPHENONE TOSYLHYDRAZONE 2',6'-DIMETHYL-3-(2-METHOXYPHENYL)PROPIOPHENONE 2'-CARBOETHOXY-3-(3,4-DIMETHYLPHENYL)PROPIOPHENONE 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 2',6'-DIMETHYL-3-(3,5-DIMETHYLPHENYL)PROPIOPHENONE 2'-CARBOETHOXY-3-(3-METHOXYPHENYL)PROPIOPHENONE 2',6'-DIMETHYL-3-(3-FLUOROPHENYL)PROPIOPHENONE 4'-Chloropropiophenone

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