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| | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Basic information | | Uses Reactions |
| Product Name: | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | | Synonyms: | 2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl ,98%;2-Dicyclohexylphosphino-2', 6-diMethoxybihenyl;2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl;Dicyclohexyl(2',6'-diMethoxy-[1,1'-biphenyl]-2-yl)phosphine;SPhos 97%;2-Dicyclohexylphosphino-2',6'-diMethoxybiphenyl, 6'-diMethoxybiphenyl;2 - dicyclohexyl phosphine - 2 ', 6 '- diMethoxy - 1, 1' - two PCB;2-Dicyclohexylphosphino-2',6'- | | CAS: | 657408-07-6 | | MF: | C26H35O2P | | MW: | 410.53 | | EINECS: | 613-838-2 | | Product Categories: | Phosphines;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts;bc0001 | | Mol File: | 657408-07-6.mol |  |
| | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties |
| Melting point | 164-166°C | | Boiling point | 513.3±40.0 °C(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Chloroform | | form | crystal | | color | white | | Sensitive | Air Sensitive | | InChIKey | VNFWTIYUKDMAOP-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 40 | | Safety Statements | 24/25-36/37 | | WGK Germany | 3 | | TSCA | No | | HS Code | 2931499090 |
| | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Usage And Synthesis |
| Uses | SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls. | | Reactions |
- Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
- Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
- Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
- Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
- Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
- Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
- Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
- Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids
- and esters.
| | Chemical Properties | White solid | | Uses | suzuki reaction | | Uses | S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment. | | General Description | SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. |
| | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials |
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