AMINOPENTAMIDE SULFATE (200 MG)

AMINOPENTAMIDE SULFATE (200 MG) Basic information
Product Name:AMINOPENTAMIDE SULFATE (200 MG)
Synonyms:Aminopentamid Sulfate;Aminopentamide;dimevamide;4-Dimethylamino-2,2-diphenylva-leramide;BL-139;Centrine;Valeramide-OM;4-(dimethylamino)-2,2-di(phenyl)pentanamide
CAS:60-46-8
MF:C19H24N2O
MW:296.41
EINECS:200-479-8
Product Categories:
Mol File:60-46-8.mol
AMINOPENTAMIDE SULFATE (200 MG) Structure
AMINOPENTAMIDE SULFATE (200 MG) Chemical Properties
Melting point 178-179℃
Boiling point 438°C (rough estimate)
density 1.069±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.5600 (estimate)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Methanol (Slightly), Water (Slightly)
pka15.73±0.50(Predicted)
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
MSDS Information
AMINOPENTAMIDE SULFATE (200 MG) Usage And Synthesis
OriginatorCentrine,Bristol,US,1953
UsesAminopentamide Sulfate affects gastric function and gastroduodenal ulcus. Used in the treatment of vomiting, diarrhea and other side effects in dogs/cats.
DefinitionChEBI: 4-(dimethylamino)-2,2-diphenylpentanamide is a diarylmethane.
Manufacturing ProcessA mixture of 14 g (0.05 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile, 16 g (0.2 mol) of sodium acetate, 14 g (0.2 mol) of hydroxylamine hydrochloride and 75 ml of ethyl alcohol was refluxed 18 hours. The mixture was cooled, poured into water and neutralized with ammonium hydroxide. The heavy white precipitate solidified on standing. The material was filtered and recrystallized from isopropanol. After three recrystallizations the aminopentamide product melted at 177° to 179°C.
The product is often used as the acid sulfate which is produced as follows: 252.0 g (0.85 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile was dissolved in one liter of isopropanol, and 70 ml of concentrated sulfuric acid was added as rapidly as possible. The mixture was heated until clear, then filtered and diluted with 1,500 ml of anhydrous ethyl acetate. The solution was cooled and filtered, and the white crystalline product was dried in vacuum over P2O5.
Therapeutic FunctionAnticholinergic
Purification MethodsCrystallise dimevamide from aqueous EtOH. The hydrochloride forms leaflets from EtOH/Et2O with m 190-191o and is deliquescent. The picrate has m 210-211o. It is an antispasmotic. [Moffett et al. J Am Chem Soc 79 4451, 4457 1957, Beckett J Pharm Pharmacol 8 848 1956, Beilstein 14 III 1363, 14 IV 1865.]
AMINOPENTAMIDE SULFATE (200 MG) Preparation Products And Raw materials
Raw materialsHydroxylamine hydrochloride
Pentanamide AMINOPENTAMIDE SULFATE (200 MG)

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.